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Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma
http://hdl.handle.net/2241/00140737
http://hdl.handle.net/2241/0014073788d6a03f-288c-4782-815c-e9391492c2d7
名前 / ファイル | ライセンス | アクション |
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VA_468-2 (3.7 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-05-10 | |||||
タイトル | ||||||
タイトル | Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Shiozawa, Toshihiro
× Shiozawa, Toshihiro× Iyama, Shinji× Toshima, Shotaro× Sakata, Akiko× Usui, Shingo× Minami, Yuko× Sato, Yukio× Hizawa, Nobuyuki× Noguchi, Masayuki |
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著者別名 |
佐藤, 幸夫
× 佐藤, 幸夫× 檜澤, 伸之× 野口, 雅之 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although embryonal proteins have been used as tumor marker, most are not useful for detection of early malignancy. In the present study, we developed mouse monoclonal antibodies against fetal lung of miniature swine, and screened them to find an embryonal protein that is produced at the early stage of malignancy, focusing on lung adenocarcinoma. We found an antibody clone that specifically stained stroma of lung adenocarcinoma. LC-MS/MS identified the protein recognized by this clone as dimethylarginine dimethylaminohydrolase 2 (DDAH2), an enzyme known for antiatherosclerotic activity. DDAH2 was found to be expressed in fibroblasts of stroma of malignancies, with higher expression in minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma than in adenocarcinoma in situ (AIS). Moreover, tumors with high stromal expression of DDAH2 had a poorer prognosis than those without. In vitro analysis showed that DDAH2 increases expression of endothelial nitric oxide synthase (eNOS), inducing proliferation and capillary-like tube formation of vascular endothelial cells. In resected human tissues, eNOS also showed higher expression in invasive adenocarcinoma than in AIS and normal lung, similarly to DDAH2. Our data indicate that expression of DDAH2 is associated with invasiveness of lung adenocarcinoma via tumor angiogenesis. DDAH2 expression might be a prognostic factor in lung adenocarcinoma. | |||||
書誌情報 |
Virchows archiv 巻 468, 号 2, p. 179-190, 発行日 2015-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0945-6317 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10992872 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26515557 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00428-015-1863-z | |||||
権利 | ||||||
権利情報 | © The Author(s) 2015. | |||||
権利 | ||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Springer Berlin Heidelberg |