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Long-term effects of traumatic stress on subsequent contextual fear conditioning in rats
http://hdl.handle.net/2241/00121610
http://hdl.handle.net/2241/001216104dcf2b95-decf-41b4-a579-248a643d325b
名前 / ファイル | ライセンス | アクション |
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PB_129.pdf (253.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2014-07-03 | |||||
タイトル | ||||||
タイトル | Long-term effects of traumatic stress on subsequent contextual fear conditioning in rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ryoke, Rie
× Ryoke, Rie× Yamada, Kazuo× Ichitani, Yukio |
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著者別名 |
山田, 一夫
× 山田, 一夫× 一谷, 幸男 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Exposure to stressful events affects subsequent sensitivity to fear. We investigated the long-term effects of a traumatic experience on subsequent contextual fear conditioning and anxiety-like behaviors in rats (Experiment 1). In addition, we tested whether the administration of the glucocorticoid synthesis inhibitor metyrapone (MET) attenuated the sensitization of fear induced by traumatic stress (Experiment 2). Male rats were subjected to a multiple stress (MS) session, which consisted of 4 foot shocks (1 mA, 1 s) and forced swimming for 20 min, followed by exposure to a situational reminder 7 days after the MS session. MET (25 or 100 mg/kg, intraperitoneal) was administered 30 min before MS. The contextual fear conditioning was performed 14 days after MS. MS enhanced the conditioned fear response for at least 14 days after the conditioning, and pretreatment with MET did not affect the enhancement of conditioned fear. These results suggest that glucocorticoid secretion triggered by MS is not involved in regulating the long-term stress-induced sensitization of fear. | |||||
書誌情報 |
Physiology & behavior 巻 129, p. 30-35, 発行日 2014-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-9384 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11537135 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24582672 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.physbeh.2014.02.042 | |||||
権利 | ||||||
権利情報 | © 2014 Elsevier Inc. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Physiology & behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Physiology & behavior 129, 2014. http://dx.doi.org/10.1016/j.physbeh.2014.02.042. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier Inc. |