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Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype
http://hdl.handle.net/2241/120549
http://hdl.handle.net/2241/120549f7216e52-4146-463a-b5fe-fd0fda569f22
名前 / ファイル | ライセンス | アクション |
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Mitochondrion_13-6.pdf (3.9 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2014-01-21 | |||||
タイトル | ||||||
タイトル | Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Takibuchi, Gaku
× Takibuchi, Gaku× Imanishi, Hirotake× Morimoto, Mami× Ishikawa, Kaori× Nakada, Kazuto× Toyama-Sorimachi, Noriko× Kikkawa, Yoshiaki× Takenaga, Keizo× Hayashi, Jun-Ichi |
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著者別名 |
瀧渕, 岳
× 瀧渕, 岳× 中田, 和人× 林, 純一 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To examine whether polymorphic mtDNA mutations that do not induce significant respiration defects regulate phenotypes of tumor cells, we used mouse transmitochondrial tumor cells (cybrids) with nuclear DNA from C57BL/6 (B6) strain and mtDNA from allogenic C3H strain. The results showed that polymorphic mutations of C3H mtDNA in the cybrids induced hypoxia sensitivity, resulting in a delay of tumor formation on their subcutaneous inoculation into B6 mice. Therefore, the effects of polymorphic mutations in normal mtDNA have to be carefully considered, particularly when we apply the gene therapy to the embryos to replace their pathogenic mtDNA by normal mtDNA. | |||||
書誌情報 |
Mitochondrion 巻 13, 号 6, p. 881-887, 発行日 2013-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1567-7249 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11694235 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 23932994 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.mito.2013.07.117 | |||||
権利 | ||||||
権利情報 | © 2013 Elsevier B.V. and Mitochondria Research Society. NOTICE: this is the author’s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, 13, 6, 2013, http://dx.doi.org/10.1016/j.mito.2013.07.117. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier Science | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/120549 | |||||
識別子タイプ | HDL |