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B23/nucleophosmin is involved in regulation of adenovirus chromatin structure at late infection stages, but not in virus replication and transcription
http://hdl.handle.net/2241/119515
http://hdl.handle.net/2241/119515b91dfe20-3838-4462-b858-e1e63ae191e0
名前 / ファイル | ライセンス | アクション |
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JGV_93-6.pdf (4.2 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2013-07-25 | |||||
タイトル | ||||||
タイトル | B23/nucleophosmin is involved in regulation of adenovirus chromatin structure at late infection stages, but not in virus replication and transcription | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Samad, Mohammad Abdus
× Samad, Mohammad Abdus× Komatsu, Tetsuro× Okuwaki, Mitsuru× Nagata, Kyosuke |
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著者別名 |
小松, 哲郎
× 小松, 哲郎× 奧脇, 暢× 永田, 恭介 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | B23/nucleophosmin has been identified in vitro as a stimulatory factor for replication of adenovirus DNA complexed with viral basic core proteins. In the present study, the in vivo function of B23 in the adenovirus life cycle was studied. It was found that both the expression of a decoy mutant derived from adenovirus core protein V that tightly associates with B23 and small interfering RNA-mediated depletion of B23 impeded the production of progeny virions. However, B23 depletion did not significantly affect the replication and transcription of the virus genome. Chromatin immunoprecipitation analyses revealed that B23 depletion significantly increased the association of viral DNA with viral core proteins and cellular histones. These results suggest that B23 is involved in the regulation of association and/or dissociation of core proteins and cellular histones with the virus genome. In addition, these results suggest that proper viral chromatin assembly, regulated in part by B23, is crucial for the maturation of infectious virus particles. | |||||
書誌情報 |
Journal of general virology 巻 93, 号 6, p. 1328-1338, 発行日 2012-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-1317 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00698722 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22337638 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1099/vir.0.036665-0 | |||||
権利 | ||||||
権利情報 | © 2012 SGM | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Society for General Microbiology | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/119515 | |||||
識別子タイプ | HDL |