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Photodynamic Therapy with Indocyanine Green Injection and Near-Infrared Light Irradiation Has Phototoxic Effects and Delays Paralysis in Spinal Metastasis
http://hdl.handle.net/2241/115305
http://hdl.handle.net/2241/115305a9703ae3-5793-4589-9cc4-f95c6312f1c2
名前 / ファイル | ライセンス | アクション |
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PLS_30-1.pdf (281.9 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-02-21 | |||||
タイトル | ||||||
タイトル | Photodynamic Therapy with Indocyanine Green Injection and Near-Infrared Light Irradiation Has Phototoxic Effects and Delays Paralysis in Spinal Metastasis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Funayama, Toru
× Funayama, Toru× Sakane, Masataka× Abe, Tetsuya× Ochiai, Naoyuki |
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著者別名 |
坂根, 正孝
× 坂根, 正孝× 落合, 直之 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: The purpose of this study was to investigate the phototoxic effects of photodynamic therapy (PDT) with indocyanine green (ICG) and near-infrared light irradiation on rat mammary adenocarcinoma cells, and its therapeutic efficacy in a rat model of spinal metastasis. Background data: Although PDT has been successfully used as a non-radiation treatment for many malignancies, it has not yet been clinically applied for treating spinal metastasis. Methods: For the phototoxicity study, CRL-1666 cells were treated with PDT and cell viability was measured by WST-1 assay. For the efficacy study, 26 female Fischer 344 rats with spinal metastasis in the L6 vertebra were divided into three treatment groups: PDT with local injection of ICG (9 rats), PDT with systemic injection of ICG (10 rats), and no treatment or control (7 rats). Both the PDT groups received near-infrared light irradiation with a total energy of 10 J (1 W for 10 sec). The light was delivered directly through a single silica probe which was set on the left side of the L6 vertebral body. Hindlimb motor function was monitored according to the Basso-Beattie-Bresnahan (BBB) scale. Further, the observation periods were calculated to determine the survival time. Results: The PDT exerted immediate and persistent phototoxic effects. Furthermore, the PDT with local injection of ICG as well as systemic injection of ICG delayed the deterioration of paralysis and prolonged the observation period. Conclusions: PDT with ICG injection and near-infrared light irradiation could be an effective local adjuvant treatment for spinal metastasis. | |||||
書誌情報 |
Photomedicine and laser surgery 巻 30, 号 1, p. 47-53, 発行日 2012 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1549-5418 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11968895 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22043821 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1089/pho.2011.3080 | |||||
権利 | ||||||
権利情報 | This is a copy of an article published in the Photomedicine and Laser Surgery © 2012 copyright Mary Ann Liebert, Inc.; Photomedicine and Laser Surgery is available online at: http://online.liebertpub.com. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Mary Ann Liebert | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/115305 | |||||
識別子タイプ | HDL |