WEKO3
アイテム
{"_buckets": {"deposit": "0080a614-5431-4e89-a90f-9efa76b0a0c6"}, "_deposit": {"id": "26023", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26023"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00026023", "sets": ["543", "1838"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2-3", "bibliographicPageEnd": "256", "bibliographicPageStart": "249", "bibliographicVolumeNumber": "51", "bibliographic_titles": [{"bibliographic_title": "Immunologic research"}]}]}, "item_5_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "渋谷, 彰"}], "nameIdentifiers": [{"nameIdentifier": "117", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80216027", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000080216027"}, {"nameIdentifier": "0000001643", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001643"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The critical role of IgM in controlling pathogen burden has been demonstrated in a variety of infection models. In the murine model of Borrelia hermsii infection, IgM is necessary and sufficient for the rapid clearance of bacteremia. Convalescent, but not naïve, B1b cells generate a specific IgM response against B. hermsii, but the mechanism of IgM-mediated protection is unknown. Here, we show that neither Fcα/μR, a high-affinity receptor for IgM, nor IgM-dependent complement activation is required for controlling B. hermsii. Bacteria in diffusion chambers with a pore size impermeable to cells were killed when diffusion chambers were implanted into either convalescent or passively immunized mice. Furthermore, adoptively transferred convalescent B1b cells in Rag1−/− mice produced specific IgM that also cleared B. hermsii in diffusion chambers independent of complement. These results demonstrate that IgM-mediated clearance of B. hermsii does not require opsonophagocytosis and indicate that a mechanism for in vivo B1b cell-mediated protection is through the generation of bactericidal IgM.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/114980"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Science+Business Media"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "22139824", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s12026-011-8260-8", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© Springer Science+Business Media, LLC 2011\nThe final publication is available at www.springerlink.com"}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0257-277X", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10738980", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "医学", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Colombo, Matthew J."}], "nameIdentifiers": [{"nameIdentifier": "89942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abraham, David"}], "nameIdentifiers": [{"nameIdentifier": "89943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibuya, Akira"}], "nameIdentifiers": [{"nameIdentifier": "89944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Alugupalli, Kishore R."}], "nameIdentifiers": [{"nameIdentifier": "89945", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "IR_51-2.pdf", "filesize": [{"value": "4.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4400000.0, "url": {"label": "IR_51-2.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/26023/files/IR_51-2.pdf"}, "version_id": "c6edd2c4-79c1-447f-a956-ad0a3f6e1527"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact"}]}, "item_type_id": "5", "owner": "1", "path": ["543", "1838"], "permalink_uri": "http://hdl.handle.net/2241/114980", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-01-31"}, "publish_date": "2012-01-31", "publish_status": "0", "recid": "26023", "relation": {}, "relation_version_is_last": true, "title": ["B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact"], "weko_shared_id": 5}
B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact
http://hdl.handle.net/2241/114980
http://hdl.handle.net/2241/1149801d15712f-3e6d-4263-a2a0-091a748e0565
名前 / ファイル | ライセンス | アクション |
---|---|---|
IR_51-2.pdf (4.4 MB)
|
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2012-01-31 | |||||
タイトル | ||||||
タイトル | B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Colombo, Matthew J.
× Colombo, Matthew J.× Abraham, David× Shibuya, Akira× Alugupalli, Kishore R. |
|||||
著者別名 |
渋谷, 彰
× 渋谷, 彰 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The critical role of IgM in controlling pathogen burden has been demonstrated in a variety of infection models. In the murine model of Borrelia hermsii infection, IgM is necessary and sufficient for the rapid clearance of bacteremia. Convalescent, but not naïve, B1b cells generate a specific IgM response against B. hermsii, but the mechanism of IgM-mediated protection is unknown. Here, we show that neither Fcα/μR, a high-affinity receptor for IgM, nor IgM-dependent complement activation is required for controlling B. hermsii. Bacteria in diffusion chambers with a pore size impermeable to cells were killed when diffusion chambers were implanted into either convalescent or passively immunized mice. Furthermore, adoptively transferred convalescent B1b cells in Rag1−/− mice produced specific IgM that also cleared B. hermsii in diffusion chambers independent of complement. These results demonstrate that IgM-mediated clearance of B. hermsii does not require opsonophagocytosis and indicate that a mechanism for in vivo B1b cell-mediated protection is through the generation of bactericidal IgM. | |||||
書誌情報 |
Immunologic research 巻 51, 号 2-3, p. 249-256, 発行日 2011-12 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0257-277X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10738980 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22139824 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12026-011-8260-8 | |||||
権利 | ||||||
権利情報 | © Springer Science+Business Media, LLC 2011 The final publication is available at www.springerlink.com |
|||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Springer Science+Business Media | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/114980 | |||||
識別子タイプ | HDL |