WEKO3
アイテム
{"_buckets": {"deposit": "60b8667d-dbf8-4e59-a384-265307334a24"}, "_deposit": {"id": "24898", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "24898"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00024898", "sets": ["340", "1657"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "1465", "bibliographicPageStart": "1461", "bibliographicVolumeNumber": "49", "bibliographic_titles": [{"bibliographic_title": "Rheumatology"}]}]}, "item_5_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "山岸, 良匡"}], "nameIdentifiers": [{"nameIdentifier": "44", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20375504", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000020375504"}, {"nameIdentifier": "0000001615", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001615"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objectives. Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and Blacks. We examined whether this finding is observed in a Japanese population, since Asians have a high reported prevalence of the T-risk allele.\n\nMethods. A total of 3923 Japanese people from the Circulatory Risk in Communities Study aged 40–90 years were genotyped for rs2231142. Associations of the rs2231142 variant with serum uric acid levels and prevalence of gout and hyperuricaemia were examined.\n\nResults. The frequency of the T-risk allele was 31% in this Japanese sample. Multivariable adjusted mean uric acid levels were 7–9 μmol/l higher for TG and TT than GG carriers (P-additive = 0.0006). The multivariable-adjusted odds ratio (OR) of prevalent gout was 1.37 (95% CI 0.68, 2.76) for TG and 4.37 (95% CI 1.98, 9.62) for TT compared with the GG carriers (P-additive = 0.001). When evaluating the combined outcome of hyperuricaemia and gout, the respective ORs were 1.40 (95% CI 1.04, 1.87) for TG and 1.88 (95% CI 1.23, 2.89) for TT carriers. The population attributable risk was 29% for gout and 19% for gout and/or hyperuricaemia.\n\nConclusions. The association of the causal ABCG2 rs2231142 variant with uric acid levels and gout was confirmed in a sample of Japanese ancestry. Our study emphasizes the importance of this common causal variant in a population with a high risk allele frequency, especially as more Japanese adopt a Western lifestyle with a concomitant increase in mean serum uric acid levels.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/113706"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "20421215", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1093/rheumatology/keq096", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org"}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1462-0324", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11316191", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "医学", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamagishi, Kazumasa"}], "nameIdentifiers": [{"nameIdentifier": "86693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanigawa, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "86694", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "86695", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Köttgen, Anna"}], "nameIdentifiers": [{"nameIdentifier": "86696", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Folsom, Aaron R."}], "nameIdentifiers": [{"nameIdentifier": "86697", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iso, Hiroyasu"}], "nameIdentifiers": [{"nameIdentifier": "86698", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "RHEUMATOLOGY_49-8.pdf", "filesize": [{"value": "183.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 183100.0, "url": {"label": "RHEUMATOLOGY_49-8.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/24898/files/RHEUMATOLOGY_49-8.pdf"}, "version_id": "49bb72cb-4241-44d0-b166-5212ae98005a"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people"}]}, "item_type_id": "5", "owner": "1", "path": ["340", "1657"], "permalink_uri": "http://hdl.handle.net/2241/113706", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-08-10"}, "publish_date": "2011-08-10", "publish_status": "0", "recid": "24898", "relation": {}, "relation_version_is_last": true, "title": ["The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people"], "weko_shared_id": 5}
The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people
http://hdl.handle.net/2241/113706
http://hdl.handle.net/2241/113706c3e9f726-c20b-4794-865e-e47c6381c1be
名前 / ファイル | ライセンス | アクション |
---|---|---|
RHEUMATOLOGY_49-8.pdf (183.1 kB)
|
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-08-10 | |||||
タイトル | ||||||
タイトル | The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yamagishi, Kazumasa
× Yamagishi, Kazumasa× Tanigawa, Takeshi× Kitamura, Akihiko× Köttgen, Anna× Folsom, Aaron R.× Iso, Hiroyasu |
|||||
著者別名 |
山岸, 良匡
× 山岸, 良匡 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives. Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and Blacks. We examined whether this finding is observed in a Japanese population, since Asians have a high reported prevalence of the T-risk allele. Methods. A total of 3923 Japanese people from the Circulatory Risk in Communities Study aged 40–90 years were genotyped for rs2231142. Associations of the rs2231142 variant with serum uric acid levels and prevalence of gout and hyperuricaemia were examined. Results. The frequency of the T-risk allele was 31% in this Japanese sample. Multivariable adjusted mean uric acid levels were 7–9 μmol/l higher for TG and TT than GG carriers (P-additive = 0.0006). The multivariable-adjusted odds ratio (OR) of prevalent gout was 1.37 (95% CI 0.68, 2.76) for TG and 4.37 (95% CI 1.98, 9.62) for TT compared with the GG carriers (P-additive = 0.001). When evaluating the combined outcome of hyperuricaemia and gout, the respective ORs were 1.40 (95% CI 1.04, 1.87) for TG and 1.88 (95% CI 1.23, 2.89) for TT carriers. The population attributable risk was 29% for gout and 19% for gout and/or hyperuricaemia. Conclusions. The association of the causal ABCG2 rs2231142 variant with uric acid levels and gout was confirmed in a sample of Japanese ancestry. Our study emphasizes the importance of this common causal variant in a population with a high risk allele frequency, especially as more Japanese adopt a Western lifestyle with a concomitant increase in mean serum uric acid levels. |
|||||
書誌情報 |
Rheumatology 巻 49, 号 8, p. 1461-1465, 発行日 2010-08 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1462-0324 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11316191 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 20421215 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/rheumatology/keq096 | |||||
権利 | ||||||
権利情報 | © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Oxford University Press | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/113706 | |||||
識別子タイプ | HDL |