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Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro
http://hdl.handle.net/2241/107526
http://hdl.handle.net/2241/107526fb9702de-bab5-46a1-82dc-1e390b775762
名前 / ファイル | ライセンス | アクション |
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IJBS_6-6.pdf (1.2 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2010-12-10 | |||||
タイトル | ||||||
タイトル | Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Jayaraman, Premkumar
× Jayaraman, Premkumar× Sakharkar, Meena K× Lim, Chu Sing× Tang, Thean Hock× Sakharkar, Kishore R. |
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著者別名 |
サクハルカル, ミーナ キショレ
× サクハルカル, ミーナ キショレ |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study the in vitro activities of seven antibiotics (ciprofloxacin, ceftazidime, tetracycline, trimethoprim, sulfamethoxazole, polymyxin B and piperacillin) and six phytochemicals (protocatechuic acid, gallic acid, ellagic acid, rutin, berberine and myricetin) against five P. aeruginosa isolates, alone and in combination are evaluated. All the phytochemicals under investigation demonstrate potential inhibitory activity against P. aeruginosa. The combinations of sulfamethoxazole plus protocatechuic acid, sulfamethoxazole plus ellagic acid, sulfamethoxazole plus gallic acid and tetracycline plus gallic acid show synergistic mode of interaction. However, the combinations of sulfamethoxazole plus myricetin shows synergism for three strains (PA01, DB5218 and DR3062). The synergistic combinations are further evaluated for their bactericidal activity against P. aeruginosa ATCC strain using time-kill method. Sub-inhibitory dose responses of antibiotics and phytochemicals individually and in combination are presented along with their interaction network to suggest on the mechanism of action and potential targets for the phytochemicals under investigation. The identified synergistic combinations can be of potent therapeutic value against P. aeruginosa infections. These findings have potential implications in delaying the development of resistance as the antibacterial effect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals). |
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書誌情報 |
International journal of biological sciences 巻 6, 号 6, p. 556-568, 発行日 2010-09-21 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1449-2288 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12036598 | |||||
権利 | ||||||
権利情報 | © Ivyspring International Publisher | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Ivyspring International Publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/107526 | |||||
識別子タイプ | HDL |