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Estrogen deficiency and low-calcium diet increased bone loss and urinary calcium excretion but did not alter arterial stiffness in young female rats
http://hdl.handle.net/2241/104448
http://hdl.handle.net/2241/104448f6762edd-f21a-4ec0-af95-448be0367ce1
名前 / ファイル | ライセンス | アクション |
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JBMM_26-3_Fig&Tab.pdf (143.9 kB)
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JBMM_26-3.pdf (218.6 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2010-03-01 | |||||
タイトル | ||||||
タイトル | Estrogen deficiency and low-calcium diet increased bone loss and urinary calcium excretion but did not alter arterial stiffness in young female rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Park, Jong-Hoon
× Park, Jong-Hoon× Omi, Naomi× Nosaka, Toshiya× Kitajima, Ayako× Ezawa, Ikuko |
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著者別名 |
麻見, 直美
× 麻見, 直美 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Many epidemiological studies have reported that the severity of arterial diseases such as arterial calcification and stiffness is inversely related to bone loss, i.e., osteoporosis. However, the nature of this relationship is unclear. The purpose of the present study was to examine the influences of estrogen deficiency and/or low-calcium diet (0.1% Ca) on bone metabolism and calcium balance, as well as aortic wall composition and stiffness in young female rats. Twenty-eight 6-week-old female rats were randomized into four groups: OVX-Low calcium (OL) and OVX-Normal calcium groups (ON) were ovariectomized, and Sham-Low calcium (SL) and Sham-Normal calcium groups (SN) were sham-operated. After 12 weeks, the bone mineral density of the lumbar spine and tibial proximal metaphysis were significantly lower in ON than in SN, and also significantly lower in OL than in ON. Additionally, OL rats had significant higher (vs. SN and SL) urinary deoxypyridinoline, but not urinary calcium, excretion at 4 weeks after ovariectomy. However, at 12 weeks after ovariectomy, urinary calcium excretion was significantly higher in OL than in SL, with corresponding increases in two bone turnover markers, bone-type alkaline phosphatase and tartrate-resistant acid phosphatase. Neither estrogen deficiency nor low-calcium diet affected aortic stiffness or elastin degeneration and calcium deposition over the course of the present study, although changes of bone metabolism occurred rapidly. Taken together, these results show that bone loss and arterial stiffness did not progress simultaneously in the present experimental protocol. | |||||
書誌情報 |
Journal of bone and mineral metabolism 巻 26, 号 3, p. 218-225, 発行日 2008-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0914-8779 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10747551 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00774-007-0822-4 | |||||
権利 | ||||||
権利情報 | © Springer 2008 | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Springer | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/104448 | |||||
識別子タイプ | HDL |