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Juvenile hormone acid O-methyltransferase in Drosophila melanogaster
http://hdl.handle.net/2241/100120
http://hdl.handle.net/2241/100120175af45e-2fbf-4c77-88e6-0fdc77936817
名前 / ファイル | ライセンス | アクション |
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IBMB_38-7.pdf (796.1 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2008-08-06 | |||||
タイトル | ||||||
タイトル | Juvenile hormone acid O-methyltransferase in Drosophila melanogaster | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Niwa, Ryusuke
× Niwa, Ryusuke× Niimi, Teruyuki× Honda, Naoko× Yoshiyama, Michiyo× Itoyama, Kyo× Kataoka, Hiroshi× Shinoda, Tetsuro |
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著者別名 |
丹羽, 隆介
× 丹羽, 隆介 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Juvenile hormone (JH) acid O-methyltransferase (JHAMT) is the enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of JH acids to produce active JHs in the corpora allata. While the JHAMT gene was originally identified and characterized in the silkworm Bombyx mori, no orthologs from other insects have been studied until now. Here we report on the functional characterization of the CG17330/DmJHAMT gene in the fruit fly Drosophila melanogaster. Recombinant DmJHAMT protein expressed in Escherichia coli catalyzes the conversion of farnesoic acid and JH III acid to their cognate methyl esters in the presence of SAM. DmJHAMT is predominantly expressed in corpora allata, and its developmental expression profile correlates with changes in the JH titer. While a transgenic RNA interference against DmJHAMT has no visible effect, overexpression of DmJHAMT results in a pharate adult lethal phenotype, similar to that obtained with application of JH analogs, suggesting that the temporal regulation of DmJHAMT is critical for Drosophila development. |
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書誌情報 |
Insect biochemistry and molecular biology 巻 38, 号 7, p. 714-720, 発行日 2008-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0965-1748 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10828030 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 18549957 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ibmb.2008.04.003 | |||||
権利 | ||||||
権利情報 | © 2008 Elsevier Ltd. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/100120 | |||||
識別子タイプ | HDL | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |