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Characterization of Osteoarthritis in a Medial Meniscectomy-Induced Animal Model Using Contrast-Enhanced X-ray Microtomography
http://hdl.handle.net/2241/00161577
http://hdl.handle.net/2241/0016157710b5dfc5-065b-4baa-a5d9-40ab26255cb3
名前 / ファイル | ライセンス | アクション |
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Biomedicines_8-3 (4.0 MB)
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2020-10-15 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Characterization of Osteoarthritis in a Medial Meniscectomy-Induced Animal Model Using Contrast-Enhanced X-ray Microtomography | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
著者 |
菅澤, 威仁
× 菅澤, 威仁× 川上, 康× 竹越, 一博
WEKO
182749
× Kuji, Tomoaki× Aoki, Kai× Yanazawa, Koki× Takenouchi, Akiko× Watanabe, Makoto× Tome, Yoshiya× Takeuchi, Yoshinori× Aita, Yuichi× Yahagi, Naoya× Shishikura, Yasuhiro× Ono, Seiko× Yoshida, Yasuko |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | The aim of this study was to clarify degradation characteristics in each tissue of the knee complex of a medial meniscectomy (MMx)-induced knee osteoarthritis (KOA) animal model using classical methods and an alternative comprehensive evaluation method called contrast-enhanced X-ray micro-computed tomography (CEX-μCT), which was developed in the study. Surgical MMx was performed in the right knee joints of five male Wistar rats to induce KOA. At four weeks post-surgery, the synovitis was evaluated using quantitative polymerase chain reaction (qPCR). Degradations of the articular cartilage of the tibial plateau were evaluated using classical methods and CEX-μCT. Evaluation of the synovitis demonstrated significantly increased expression levels of inflammation-associated marker genes in MMx-treated knees compared with those in sham-treated knees. Evaluation of the articular cartilage using classical methods showed that MMx fully induced degradation of the cartilage. Evaluation using CEX-μCT showed that local areas of the medial cartilage of the tibial plateau were significantly reduced in MMx-treated knees compared with those in sham-treated knees. On the other hand, total cartilage volumes were significantly increased in MMx-treated knees. On the basis of the findings of this study, the method could be relevant to study new treatments in KOA research. | |||||||||||
書誌情報 |
en : Biomedicines 巻 8, 号 3, p. 56, 発行日 2020-03 |
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ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 2227-9059 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 32164328 | |||||||||||
DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.3390/biomedicines8030056 | |||||||||||
権利 | ||||||||||||
権利情報 | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||
著者版フラグ | ||||||||||||
値 | publisher | |||||||||||
出版者 | ||||||||||||
出版者 | MDPI |