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Factors associated with recurrent leptomeningeal metastases in patients with EGFR-mutated non–small-cell lung cancer
http://hdl.handle.net/2241/00161302
http://hdl.handle.net/2241/00161302bb99b48d-3794-416c-ae69-fe8297bd0e39
名前 / ファイル | ライセンス | アクション |
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PAIM_129-11 (129.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Factors associated with recurrent leptomeningeal metastases in patients with EGFR-mutated non–small-cell lung cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
佐藤, 浩昭
× 佐藤, 浩昭× 檜澤, 伸之× Watanabe, Hiroko× Okauchi, Shinichiro× Miyazaki, Kunihiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) was shown to increase the number of long-term survivors among patients with non–small-cell lung cancer (NSCLC) associated with the mutation of the EGFR gene.1 However, considering the limitations of current medical technology, it is difficult to expect a cure for this disease.2 In most patients, the regrowth of the primary tumor and metastases are observed. Unfortunately, depending on the site of recurrence, treatment of numerous patients with severe metastasis is difficult. Recurrent leptomeningeal metastases are particularly challenging. Meningeal metastasis is defined as a condition in which tumor cells have spread and invaded the surface of the brain and subarachnoid space, and then the ventricles and cisterns via the cerebrospinal fluid.3 The metastasis causes various neurologic symptoms and is often difficult to diagnose.3 As there is no established treatment for cancer recurrence after an effective therapy with an EGFR-TKI, patients may experience a reduced quality of life, become bedridden, and eventually die.3 Therefore, it is important to identify factors that are related to cancer recurrence. In this study, in addition to standard clinicopathological factors, we examined factors related to recurrence in the meninges, which is associated with metastases to other organs. | |||||
書誌情報 |
Polskie archiwum medycyny wewnȩtrznej en : Polish archives of internal medicine 巻 129, 号 11, p. 836-838, 発行日 2019-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0032-3772 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1897-9483 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00776928 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31456585 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.20452/pamw.14948 | |||||
権利 | ||||||
権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 International License (CC BY‑NC‑SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only. For commercial use, please contact the journal office at pamw@mp.pl. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Medycyna Praktyczna |