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Experimental rat model for cervical compressive myelopathy
http://hdl.handle.net/2241/00159835
http://hdl.handle.net/2241/001598350202c3ac-5e43-413b-a671-0615791a3608
名前 / ファイル | ライセンス | アクション |
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Neuroreport_28-18 (405.8 kB)
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2020-03-26 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Experimental rat model for cervical compressive myelopathy | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
著者 |
國府田, 正雄
× 國府田, 正雄× 山崎, 正志
WEKO
204981
× Ijima, Yasushi× Furuya, Takeo× Matsuura, Yusuke× Saito, Junya× Kitamura, Mitsuhiro× Miyamoto, Takuya× Orita, Sumihisa× Inage, Kazuhide× Suzuki, Takane× Ohtori, Seiji |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Previously, a rat model of chronic compressive myelopathy that uses a water-absorbing polymer inserted under a spinal lamina was reported. However, the best size and coefficient of expansion of the polymer sheet have not yet been established. The aim of the present study was to optimize these properties in an ideal rat model of cervical compressive myelopathy. Thirty rats were used in this study. A sheet of water-absorbing polymer was inserted under the cervical laminae. Rats were divided randomly into five experimental groups by the expansion rate (350 or 200%) and thickness (0.5 or 0.7 mm) and the control. After the surgery, the severity of paralysis was evaluated for 12 weeks. At 12 weeks after the surgery, cresyl violet staining was performed to assess the number of motor neurons in the anterior horn at the C4/C5 segment and Luxol Fast Blue staining was performed to assess demyelination in the corticospinal tract at the C7 segment. ‘Slow-progressive’ paralysis appeared at 4–8 weeks postoperatively in rat models using sheets with 200% expansion. By contrast, only temporary paralysis was observed in rat models using sheets with 350% expansion. A loss of motor neurons in the anterior horn was observed in all groups, except for the control. Demyelination in the corticospinal tract was observed in rat models using sheets with 200% expansion, but not rat models using sheets with 350% expansion. A polymer sheet that expands its volume by 200% is an ideal material for rat models of cervical compressive myelopathy. | |||||||||||
書誌情報 |
en : Neuroreport 巻 28, 号 18, p. 1239-1245, 発行日 2017-12 |
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ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 0959-4965 | |||||||||||
書誌レコードID | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA10850958 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 28957944 | |||||||||||
DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.1097/WNR.0000000000000907 | |||||||||||
権利 | ||||||||||||
権利情報 | © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. | |||||||||||
権利 | ||||||||||||
権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. | |||||||||||
著者版フラグ | ||||||||||||
値 | publisher | |||||||||||
出版者 | ||||||||||||
出版者 | Lippincott Williams & Wilkins |