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Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells
http://hdl.handle.net/2241/00157874
http://hdl.handle.net/2241/001578742cb1654e-99c0-47e1-bf59-1cfb2c60cd7f
名前 / ファイル | ライセンス | アクション |
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JTS_44-5 (1.9 MB)
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2019-10-18 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
著者 |
熊谷, 嘉人
× 熊谷, 嘉人× 新開, 泰弘
WEKO
133157
× Fujie, Tomoya× Takenaka, Fukuta× Yoshida, Eiko× Yasuike, Shuji× Fujiwara, Yasuyuki× Yamamoto, Chika× Kaji, Toshiyuki |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Metallothionein (MT) is a low-molecular-weight, cysteine-rich, and metal-binding protein that protects cells from the cytotoxic effects of heavy metals and reactive oxygen species. Previously, we found that transcriptional induction of endothelial MT-1A was mediated by not only the metal-regulatory transcription factor 1 (MTF-1)-metal responsive element (MRE) pathway but also the nuclear factor-erythroid 2-related factor 2 (Nrf2)-antioxidant response element/electrophile responsive element (ARE) pathway, whereas that of MT-2A was mediated only by the MTF-1-MRE pathway, using the organopnictogen compounds tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane as molecular probes in vascular endothelial cells. In the present study, we investigated the binding sites of MTF-1 and Nrf2 in the promoter regions of MTs in cultured bovine aortic endothelial cells treated with these organopnictogen compounds. We propose potential mechanisms underlying transcriptional induction of endothelial MT isoforms. Specifically, both MRE activation by MTF-1 and that of ARE in the promoter region of the MT-2A gene by Nrf2 are involved in transcriptional induction of MT-1A, whereas only MRE activation by MTF-1 or other transcriptional factor(s) is required for transcriptional induction of MT-2A in vascular endothelial cells. | |||||||||||
書誌情報 |
en : The Journal of Toxicological Sciences 巻 44, 号 5, p. 327-333, 発行日 2019 |
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ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 0388-1350 | |||||||||||
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収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AN00002808 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 31068538 | |||||||||||
DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.2131/jts.44.327 | |||||||||||
著者版フラグ | ||||||||||||
値 | publisher | |||||||||||
出版者 | ||||||||||||
出版者 | The Japanese Society of Toxicology | |||||||||||
出版者別名 | ||||||||||||
出版者 | 日本毒性学会 |