WEKO3
アイテム
{"_buckets": {"deposit": "e79a2a11-f1db-4650-bd4d-2edf4991ef47"}, "_deposit": {"id": "51976", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "51976"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00051976", "sets": ["2179", "7600"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageStart": "350", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "Viruses"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recent large-scale genomics studies of human papillomaviruses (HPVs) have shown a high level of genomic variability of HPV16, the most prevalent genotype in HPV-associated malignancies, and provided new insights into the biological and clinical relevance of its genetic variations in cervical cancer development. Here, we performed deep sequencing analyses of the viral genome to explore genetic variations of HPV16 that are prevalent in Japan. A total of 100 complete genome sequences of HPV16 were determined from cervical specimens collected from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer, or without cervical malignancies. Phylogenetic analyses revealed the variant distribution in the Japanese HPV16 isolates; overall, lineage A was the most prevalent (94.0%), in which sublineage A4 was dominant (52.0%), followed by sublineage A1 (21.0%). The relative risk of sublineage A4 for cervical cancer development was significantly higher compared to sublineages A1/A2/A3 (odds ratio = 6.72, 95% confidence interval = 1.78–28.9). Interestingly, a novel cluster of variants that branched from A1/A2/A3 was observed for the Japanese HPV16 isolates, indicating that unique HPV16 variants are prevalent among Japanese women.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "30995759", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3390/v11040350", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1999-4915", "subitem_source_identifier_type": "ISSN"}]}, "item_5_subject_20": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "医学", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "佐藤, 豊実"}, {"creatorName": "サトウ, トヨミ", "creatorNameLang": "ja-Kana"}, {"creatorName": "SATOH, Toyomi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "742", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80344886", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000080344886"}, {"nameIdentifier": "0000001922", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001922"}]}, {"creatorNames": [{"creatorName": "Hirose, Yusuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214006", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Onuki, Mamiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214007", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tenjimbayashi, Yuri", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214008", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaguchi-Naka, Mayuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214009", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Seiichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214010", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tasaka, Nobutaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214011", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morisada, Tohru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214012", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwata, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyono, Tohru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214014", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimura, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sekizawa, Akihiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Koji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214017", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kukimoto, Iwao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214018", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Viruses_11-4.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "Viruses_11-4", "url": "https://tsukuba.repo.nii.ac.jp/record/51976/files/Viruses_11-4.pdf"}, "version_id": "c57f505f-35db-435e-95e1-7081b5552867"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions"}]}, "item_type_id": "5", "owner": "1", "path": ["2179", "7600"], "permalink_uri": "http://hdl.handle.net/2241/00157405", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-08-26"}, "publish_date": "2019-08-26", "publish_status": "0", "recid": "51976", "relation": {}, "relation_version_is_last": true, "title": ["Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions"], "weko_shared_id": 5}
Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions
http://hdl.handle.net/2241/00157405
http://hdl.handle.net/2241/001574051968d1c2-1778-43b1-b44e-26ac185fa286
名前 / ファイル | ライセンス | アクション |
---|---|---|
Viruses_11-4 (1.4 MB)
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-08-26 | |||||
タイトル | ||||||
タイトル | Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
佐藤, 豊実
× 佐藤, 豊実× Hirose, Yusuke× Onuki, Mamiko× Tenjimbayashi, Yuri× Yamaguchi-Naka, Mayuko× Mori, Seiichiro× Tasaka, Nobutaka× Morisada, Tohru× Iwata, Takashi× Kiyono, Tohru× Mimura, Takashi× Sekizawa, Akihiko× Matsumoto, Koji× Kukimoto, Iwao |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent large-scale genomics studies of human papillomaviruses (HPVs) have shown a high level of genomic variability of HPV16, the most prevalent genotype in HPV-associated malignancies, and provided new insights into the biological and clinical relevance of its genetic variations in cervical cancer development. Here, we performed deep sequencing analyses of the viral genome to explore genetic variations of HPV16 that are prevalent in Japan. A total of 100 complete genome sequences of HPV16 were determined from cervical specimens collected from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer, or without cervical malignancies. Phylogenetic analyses revealed the variant distribution in the Japanese HPV16 isolates; overall, lineage A was the most prevalent (94.0%), in which sublineage A4 was dominant (52.0%), followed by sublineage A1 (21.0%). The relative risk of sublineage A4 for cervical cancer development was significantly higher compared to sublineages A1/A2/A3 (odds ratio = 6.72, 95% confidence interval = 1.78–28.9). Interestingly, a novel cluster of variants that branched from A1/A2/A3 was observed for the Japanese HPV16 isolates, indicating that unique HPV16 variants are prevalent among Japanese women. | |||||
書誌情報 |
Viruses 巻 11, 号 4, p. 350, 発行日 2019-04 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1999-4915 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30995759 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/v11040350 | |||||
権利 | ||||||
権利情報 | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | MDPI |