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Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion
http://hdl.handle.net/2241/00157402
http://hdl.handle.net/2241/00157402c6ecf6de-6d3d-4c0e-8a4f-b44e69bfccdf
名前 / ファイル | ライセンス | アクション |
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JCB_218-5-1670 (4.4 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-08-26 | |||||
タイトル | ||||||
タイトル | Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
大庭, 良介
× 大庭, 良介× Chuang, Mei-Chun× Lin, Shan-Shan× Lee, Gang-Hui× Su, You-An× Chang, Yu-Chen× Tang, Ming-Jer× Liu, Ya-Wen |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Skeletal muscle development requires the cell–cell fusion of differentiated myoblasts to form muscle fibers. The actin cytoskeleton is known to be the main driving force for myoblast fusion; however, how actin is organized to direct intercellular fusion remains unclear. Here we show that an actin- and dynamin-2–enriched protrusive structure, the invadosome, is required for the fusion process of myogenesis. Upon differentiation, myoblasts acquire the ability to form invadosomes through isoform switching of a critical invadosome scaffold protein, Tks5. Tks5 directly interacts with and recruits dynamin-2 to the invadosome and regulates its assembly around actin filaments to strengthen the stiffness of dynamin-actin bundles and invadosomes. These findings provide a mechanistic framework for the acquisition of myogenic fusion machinery during myogenesis and reveal a novel structural function for Tks5 and dynamin-2 in organizing actin filaments in the invadosome to drive membrane fusion. | |||||
書誌情報 |
The journal of cell biology 巻 218, 号 5, p. 1670-1685, 発行日 2019-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-9525 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00694812 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30894403 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1083/jcb.201809161 | |||||
権利 | ||||||
権利情報 | © 2019 Chuang et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Rockefeller University Press |