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4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation
http://hdl.handle.net/2241/00157096
http://hdl.handle.net/2241/00157096a1c69248-0a17-417a-b57c-f86b945a79f6
名前 / ファイル | ライセンス | アクション |
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Cy_71-1 (634.5 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-07-12 | |||||
タイトル | ||||||
タイトル | 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
宮崎, 均
× 宮崎, 均× 吉田, 滋樹× Hagiwara, Hiromi× Nakata, Kyoko× Maehashi, Sanae× Komiyama, Yuki× Aida, Rieko× Kokubu, Daichi× Hagiwara, Keitaro× Yoshida, Kaoru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 4-Hydroxyderricin (4-HD) is a major polyphenol of Angelica keiskei (Japanese name Ashitaba), exhibiting anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. The present study was designed to evaluate the effects of 4-HD on bone formation and maintenance by using cultured osteoclasts and osteoblasts. 4-HD did not affect cell proliferation of stromal ST2 cells and preosteoblast MC3T3-E1 cells at concentrations of 1–10 μM. This compound inhibited the formation of multinucleated osteoclasts from mouse splenic cells, and we identified a molecular pathway of osteoclast differentiation mediated by 4-HD, which led to inhibition of the expression of receptor activator of nuclear factor-κB ligand and macrophage-colony stimulating factor in ST2 cells. By contrast, 4-HD enhanced indices of osteoblast differentiation, such as alkaline phosphatase activity and calcium deposition by osteoblastic MC3T3-E1 cells, at concentrations of 1–10 μM. Furthermore, we found that 4-HD at 1 μM attenuated H2O2 levels in MC3T3-E1 cells. Our findings indicate that 4-HD may have critical effects on bone formation and maintenance. | |||||
書誌情報 |
Cytotechnology 巻 71, 号 1, p. 15-22, 発行日 2019-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0920-9069 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10678299 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30474804 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10616-018-0236-2 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2018 | |||||
権利 | ||||||
権利情報 | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Springer |