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Nonfasting Glucose and Incident Stroke and Its Types : The Circulatory Risk in Communities Study (CIRCS)
http://hdl.handle.net/2241/00155144
http://hdl.handle.net/2241/001551443d6347d7-9601-404c-bc24-4c1f9b5100d7
名前 / ファイル | ライセンス | アクション |
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Circ_82-1598 (342.8 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-04-18 | |||||
タイトル | ||||||
タイトル | Nonfasting Glucose and Incident Stroke and Its Types : The Circulatory Risk in Communities Study (CIRCS) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
山岸, 良匡
× 山岸, 良匡× 山海, 知子× Imano, Hironori× Iso, Hiroyasu× Kitamura, Akihiko× Hayama-Terada, Mina× Muraki, Isao× Okada, Takeo× Umesawa, Mitsumasa× Ohira, Tetsuya× Cui, Renzhe× Tanigawa, Takeshi× Kiyama, Masahiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background:The effect of postprandial glucose on the risk of cardiovascular disease has been emphasized, but it is controversial whether nonfasting glucose is related to incident stroke and its types. Methods and Results:We investigated the associations of nonfasting glucose with incident stroke and its types among 7,198 participants aged 40–74 years from the Circulatory Risk in Communities Study, enrolled in 1995–2000. We estimated multivariable hazard ratios (HR) using Cox proportional hazard models. Over a median follow-up of 14.1 years, 291 cases of total stroke (ischemic strokes: 191 including 109 lacunar infarctions) were identified. Nonfasting glucose concentration was associated with greater risk of incident total stroke, ischemic stroke and lacunar infarction when modeled categorically (for prediabetic type: 7.8–11.0 mmol/L vs. normal type: <7.8 mmol/L among all subjects, HR for lacunar infarction was 2.02, 95% confidence interval (CI): 1.19, 3.43) or continuously (per one standard deviation increment among all subjects, HR for lacunar infarction was 1.29, 95% CI: 1.15, 1.45). Diabetic type showed similar results. Population attributable fractions of nonfasting hyperglycemia were 13.2% for ischemic stroke and 17.4% for lacunar infarction. Conclusions:Nonfasting glucose concentration, either as a diagnosis of prediabetic and diabetic types or as a continuous variable, proved to be an independent predictor significantly attributed to incident total stroke, especially ischemic stroke and lacunar infarction, in the general population. |
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書誌情報 |
Circulation journal 巻 82, 号 6, p. 1598-1604, 発行日 2018-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-9843 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1253/circj.CJ-17-0950 | |||||
権利 | ||||||
権利情報 | All rights are reserved to the Japanese Circulation Society. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | The Japanese Circulation Society. |