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Serum α-linolenic and other ω-3 fatty acids, and risk of disabling dementia: Community-based nested case–control study
http://hdl.handle.net/2241/00155097
http://hdl.handle.net/2241/00155097df59961e-cda7-41e7-b539-79e3e8660733
名前 / ファイル | ライセンス | アクション |
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CN_36-3 (241.8 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-04-11 | |||||
タイトル | ||||||
タイトル | Serum α-linolenic and other ω-3 fatty acids, and risk of disabling dementia: Community-based nested case–control study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
山岸, 良匡
× 山岸, 良匡× 山海, 知子× Ikeda, Ai× Chei, Choy-Lye× Noda, Hiroyuki× Umesawa, Mitsumasa× Cui, Renzhe× Muraki, Isao× Ohira, Tetsuya× Imano, Hironori× Okada, Takeo× Tanigawa, Takeshi× Kitamura, Akihiko× Kiyama, Masahiko× Iso, Hiroyasu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background & aims It has been hypothesized that ω-3 polyunsaturated fatty acids have anti-atherosclerotic and neuronal protective functions and may benefit prevention of dementia, but the epidemiological evidence, especially for α-linolenic acid, is quite limited. The aim of this study was to examine whether serum ω-3 polyunsaturated fatty acids are associated with risk of dementia. Methods We performed an intracohort case–control study nested in a community-based cohort, the Circulatory Risk in Communities Study, involving 7586 Japanese individuals aged 40–74 years at the baseline period of 1984–1994. Omega-3 polyunsaturated fatty acid constituents (α-linolenic, eicosapentaenoic, and docosahexaenoic acids) in serum total lipid were measured in 315 cases of incident disabling dementia in the above-mentioned cohort between 1999 and 2004, and in 630 controls whose age, sex, area, and baseline year were matched with the cases. Results As we had postulated, serum α-linolenic acid was inversely associated with risk of disabling dementia: the multivariate odds ratios (95% confidence intervals) were 0.57 (0.39–0.85), 0.51 (0.34–0.76), and 0.61 (0.41–0.90) for persons with the second, third, and highest quartiles of serum α-linolenic acid, respectively, as compared with the lowest quartile (P for trend = 0.01). Associations of other ω-3 fatty acids with disabling dementia were not statistically significant. Conclusions Serum α-linolenic acid was inversely associated with risk of disabling dementia. Although the causality needs to be confirmed by randomized control trials, we identified serum α-linolenic acid as a biomarker that predicts future dementia. |
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書誌情報 |
Clinical nutrition 巻 36, 号 3, p. 793-797, 発行日 2017-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0261-5614 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10643818 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27265182 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.clnu.2016.05.011 | |||||
権利 | ||||||
権利情報 | ©2017 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier |