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Characterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7
http://hdl.handle.net/2241/00154942
http://hdl.handle.net/2241/00154942823d886f-c445-41e1-96b2-abae2c8a9db8
名前 / ファイル | ライセンス | アクション |
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B&P_109 (2.0 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-04-04 | |||||
タイトル | ||||||
タイトル | Characterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
雷, 中方
× 雷, 中方× 張, 振亜× Sun, Shuang× Li, Kejuan× Xiao, Long |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Helicteres angustifolia L. (H. angustifolia) has been widely used as a remedy against various types of illness relating to immune response, such as inflammations and fever. In order to characterize the structure and identify the immunomodulatory activity of polysaccharide from H. angustifolia, a polysaccharide fraction (SPF3-1) was purified from H. angustifolia by using DEAE Sepharose Fast Flow and Sephacry S-400 chromatography, successively. Physicochemical analysis demonstrated that SPF3-1 is an acidic heteropolysaccharide with a molecular weight of about 13.36 kDa; in vitro immunomodulatory assay reflects that SPF3-1 could significantly (p < 0.05) enhance the proliferation of macrophages, stimulate the macrophages phagocytic capacity, as well as induce NO and immunomodulatory cytokines generation. All the results suggest that SPF3-1 from H. angustifolia possesses potent immunomodulatory activity and could be further developed as new products for medicines or functional foods. | |||||
書誌情報 |
Biomedicine & pharmacotherapy 巻 109, p. 262-270, 発行日 2019-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0753-3322 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10506249 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30396084 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.biopha.2018.10.039 | |||||
権利 | ||||||
権利情報 | © 2018 Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Elsevier |