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Paradoxical response to osimertinib therapy in a patient with T790M‑mutated lung adenocarcinoma
http://hdl.handle.net/2241/00154783
http://hdl.handle.net/2241/00154783cf05b697-4626-48ba-a09c-c25b7ca839c3
名前 / ファイル | ライセンス | アクション |
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MCO_8-1-175 (496.9 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-03-06 | |||||
タイトル | ||||||
タイトル | Paradoxical response to osimertinib therapy in a patient with T790M‑mutated lung adenocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
川口, 未央
× 川口, 未央× 佐藤, 浩昭× Okauchi, Shinichiro× Osawa, Hajime× Miyazaki, Kunihiko× Kawaguchi, Mio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A ‘paradoxical response’ to cancer treatment is a term used to describe the emergence of unexpected new lesions and the progression of existing lesions, despite appropriate and effective therapy. ‘Pseudo‑progression’ is a phenomenon in which lymphocytes activated by an immune checkpoint inhibitor accumulate in a tumor and expand its shadow, mimicking enlargement of the primary lesion or development of a new metastatic lesion. Patients receiving cancer chemotherapy may respond differently to treatment, by exhibiting a response, deterioration, or the simultaneous occurrence of both. These variations may be attributed to the heterogeneity of the cancer. However, differences in the temporary response to epidermal growth factor receptor‑tyrosine kinase inhibitor (EGFR‑TKI) treatment are rarely observed. If such a phenomenon is observed, it should not affect the evaluation of the therapeutic effect or be considered as an indication for the discontinuation of treatment. We herein report a rare case of a transient increase in carcinomatous pleural fluid as a paradoxical response to osimertinib treatment in a patient with T790M‑mutated lung adenocarcinoma. The primary lesion and pulmonary metastases responded well to therapy. Although this paradoxical response is very rare, of non‑malignant nature, and does not usually require treatment modification of, physicians must acknowledge that it is not a clinically discouraging characteristic when using EGFR‑TKI to treat T790M‑mutated lung adenocarcinoma. | |||||
書誌情報 |
Molecular and clinical oncology 巻 8, 号 1, p. 175-177, 発行日 2018-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2049-9450 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12610944 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29285395 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/mco.2017.1474 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Spandidos Publications |