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Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
http://hdl.handle.net/2241/00154077
http://hdl.handle.net/2241/00154077ca35dab4-dadb-4662-bf02-b4147cadfb33
名前 / ファイル | ライセンス | アクション |
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AN_131-2 (2.0 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-12-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Taniguchi-Watanabe, Sayuri
× Taniguchi-Watanabe, Sayuri× 新井, 哲明× Kametani, Fuyuki× Nonaka, Takashi× Masuda-Suzukake, Masami× Tarutani, Airi× Murayama, Shigeo× Saito, Yuko× Arima, Kunimasa× Yoshida, Mari× Akiyama, Haruhiko× Robinson, Andrew× Mann, David M. A.× Iwatsubo, Takeshi× Hasegawa, Masato |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset of neurodegenerative diseases. We have analyzed pathological tau in Alzheimer’s disease, and in frontotemporal lobar degeneration associated with tauopathy to include cases with Pick bodies, corticobasal degeneration, progressive supranuclear palsy, and ones due to intronic mutations in MAPT. We found that the C-terminal band pattern of the pathological tau species is distinct for each disease. Immunoblot analysis of trypsin-resistant tau indicated that the different band patterns of the 7–18 kDa fragments in these diseases likely reflect different conformations of tau molecular species. Protein sequence and mass spectrometric analyses revealed the carboxyl-terminal region (residues 243–406) of tau comprises the protease-resistant core units of the tau aggregates, and the sequence lengths and precise regions involved are different among the diseases. These unique assembled tau cores may be used to classify and diagnose disease strains. Based on these results, we propose a new clinicopathological classification of tauopathies based on the biochemical properties of tau. | |||||
言語 | en | |||||
書誌情報 |
en : Acta neuropathologica 巻 131, 号 2, p. 267-280, 発行日 2016-02 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0001-6322 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508984 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26538150 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00401-015-1503-3 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © The Author(s) 2015. This article is published with open access at Springerlink.com | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons. org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer |