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Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice
http://hdl.handle.net/2241/00153690
http://hdl.handle.net/2241/001536904c64bb66-b392-49d6-84c4-a3a4a0a51b05
名前 / ファイル | ライセンス | アクション |
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InterImmu_30-9 (1.7 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-11-15 | |||||
タイトル | ||||||
タイトル | Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hitomi, Kaori
× Hitomi, Kaori× Tahara-Hanaoka, Satoko× Miki, Haruka× Iwata, Kanako× Shibayama, Shiro× Kubo, Masato× Shibuya, Akira |
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著者別名 |
田原, 聡子
× 田原, 聡子× 渋谷, 彰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR. | |||||
書誌情報 |
International immunology 巻 30, 号 9, p. 429-434, 発行日 2018-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0953-8178 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10730708 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30169732 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/intimm/dxy025 | |||||
権利 | ||||||
権利情報 | © The Japanese Society for Immunology. 2018. | |||||
権利 | ||||||
権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record International Immunology, Volume 30, Issue 9, 30 August 2018, Pages 429–434 is available online at: https://doi.org/10.1093/intimm/dxy025. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Oxford University Press |