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Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
http://hdl.handle.net/2241/00151531
http://hdl.handle.net/2241/00151531429c15ee-5558-4ebf-a8ac-12d4df05dbf3
名前 / ファイル | ライセンス | アクション |
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DMSOTT_2018-11 (337.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-04-27 | |||||
タイトル | ||||||
タイトル | Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ueda, Keisuke
× Ueda, Keisuke× Sasai, Hiroyuki× Tsujimoto, Takehiko× Sanbongi, Chiaki× Ikegami, Shuji× Kobayashi, Hiroyuki× Shioya, Nobuhiko× Suzuki, Satoru× Nakata, Yoshio |
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著者別名 |
小林, 裕幸
× 小林, 裕幸× 中田, 由夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: The purpose of this study was to test the efficacy of arginine, alanine, and phenylalanine mixture (A-mix) ingestion at 1,500 mg/day in combination with the promotion of physical activity for abdominal fat reduction in overweight adults. Methods: A placebo-controlled, double-blind, parallel-group, randomized trial for 12 weeks combined with a 4-week follow-up period was conducted at a single center in Minato-ku, Tokyo, Japan, between December 2016 and May 2017. Data were analyzed between June and August 2017. The study participants were 200 overweight adults within the age range of 20–64 years. The participants were randomly assigned to the A-mix group (n=100) or a placebo group (n=100) and were administered 500 mL of test beverage containing 1,500 or 0 mg of A-mix, respectively, for 12 weeks. All participants maintained a physically active lifestyle between week 0 and week 12 through monthly sessions of physical activity. The primary outcomes were the 12-week changes in the abdominal total, subcutaneous, and visceral fat areas, as assessed by computed tomography. Results: Of the 200 enrolled participants, 199 (99%) accomplished the 12-week intervention and 4-week follow-up period. The per-protocol-based analysis for 194 participants demonstrated that the abdominal total fat area decreased significantly in the A-mix group compared with that in the placebo group (difference, 10.0 cm2; 95% confidence interval [CI]: 0.4–19.6 cm2; P=0.041). Comparable outcomes were obtained for the abdominal subcutaneous fat area (difference, 7.4 cm2; 95% CI: 0.1–14.7 cm2; P=0.047). No study-related unfavorable events occurred. Conclusion: A-mix supplementation in combination with physical activity promotion facilitated abdominal fat reduction in overweight adults. |
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書誌情報 |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 巻 11, p. 23-33, 発行日 2018-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1178-7007 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29520158 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/DMSO.S153151 | |||||
権利 | ||||||
権利情報 | © 2018 Ueda et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Dove Press Ltd |