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Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population
http://hdl.handle.net/2241/00151485
http://hdl.handle.net/2241/0015148540a9b470-2b86-40f3-a5e1-1c4c6d90f213
名前 / ファイル | ライセンス | アクション |
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MGG_293-2 (618.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-04-24 | |||||
タイトル | ||||||
タイトル | Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yasukochi, Yoshiki
× Yasukochi, Yoshiki× Sakuma, Jun× Takeuchi, Ichiro× Kato, Kimihiko× Oguri, Mitsutoshi× Fujimaki, Tetsuo× Horibe, Hideki× Yamada, Yoshiji |
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著者別名 |
佐久間, 淳
× 佐久間, 淳 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chronic kidney disease and hyperuricemia are serious global health problems. Recent genome-wide association studies have identified various genetic variants related to these disorders. However, most studies have been conducted in a cross-sectional manner. To identify novel susceptibility loci for chronic kidney disease or hyperuricemia, we performed longitudinal exome-wide association studies (EWASs), using ~ 244,000 genetic variants and clinical data of Japanese individuals who had undergone annual health checkups for several years. After establishing quality controls, the association of renal function-related traits in 5648 subjects (excluding patients with dialysis and population outliers) with 24,579 single nucleotide variants (SNVs) for three genetic models (P < 3.39 × 10− 7) was tested using generalized estimating equation models. The longitudinal EWASs revealed novel relations of five SNVs to renal function-related traits. Cross-sectional data for renal function-related traits in 7699 Japanese subjects were examined in a replication study. Among the five SNVs, rs55975541 in CDC42BPG was significantly (P < 4.90 × 10− 4) related to the serum concentration of uric acid in the replication cohort. We also examined the SNVs detected in our longitudinal EWASs with the information on P values in GKDGEN meta-analysis data. Four SNVs in SLC15A2 were significantly associated with the estimated glomerular filtration rate in European ancestry populations, although these SNVs were related to the serum concentration of uric acid with borderline significance in our longitudinal EWASs. Our findings indicate that CDC42BPG may be a novel susceptibility locus for hyperuricemia. | |||||
書誌情報 |
Molecular Genetics and Genomics 巻 293, 号 2, p. 371-379, 発行日 2018-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1617-4615 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11547886 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29124443 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00438-017-1394-1 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2017. This article is an open access publication | |||||
権利 | ||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://crea- tivecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appro- priate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Springer |