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Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kit W-sh/W-sh mice
http://hdl.handle.net/2241/00151258
http://hdl.handle.net/2241/00151258953c65db-e8cd-4453-9ac9-d1958d8d0f38
名前 / ファイル | ライセンス | アクション |
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InterImmu_29-5 (2.6 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-04-16 | |||||
タイトル | ||||||
タイトル | Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kit W-sh/W-sh mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Shibagaki, Shohei
× Shibagaki, Shohei× Tahara-Hanaoka, Satoko× Hiroyama, Takashi× Nakamura, Yukio× Shibuya, Akira |
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著者別名 |
田原, 聡子
× 田原, 聡子× 渋谷, 彰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Mast cells (MCs) play pivotal roles in allergic reactions and the host defense against microbial infection through the IgE-dependent and IgE-independent signaling pathways. MC lines that can be analyzed both in vitro and in vivo would be useful for the study of MC-dependent immune responses. Here, we investigated the functional characteristics of a mouse embryonic stem cell-derived MC-like cell line, MEDMC-BRC6. The cell line expressed FcεRI and c-Kit and showed degranulation and production of inflammatory cytokines and chemokines, including TNF-α, IL-6 and MCP-1, upon cross-linking FcεRI with IgE. These cytokines and chemokines were also produced by the cell line by stimulation of TLR2 and TLR4. MEDMC-BRC6 survived in the peritoneal cavity and the ear skin for at least 6 months after the transfer into genetically compatible MC-deficient KitW-sh/W-sh mice, in which systemic anaphylaxis was successfully induced. Thus, MEDMC-BRC6 cells represent a potent tool for investigating the functions of MCs in vitro and in vivo. | |||||
書誌情報 |
International immunology 巻 29, 号 5, p. 235-242, 発行日 2017-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0953-8178 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10730708 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28431112 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/intimm/dxx022 | |||||
権利 | ||||||
権利情報 | © The Japanese Society for Immunology. 2017. | |||||
権利 | ||||||
権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record International Immunology, Volume 29, Issue 5, 1 May 2017, Pages 235–242 is available online at: https://doi.org/10.1093/intimm/dxx022. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Oxford University Press |