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High-sensitivity quantitative analysis reveals the non-linear relationship between the dose and deposition of diphenylarsinic acid in the rat central nervous system following its subchronic exposure
http://hdl.handle.net/2241/00151083
http://hdl.handle.net/2241/00151083d15c9cf0-c147-4c12-869f-fd6a16dd0836
名前 / ファイル | ライセンス | アクション |
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NT_65 (479.4 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-03-29 | |||||
タイトル | ||||||
タイトル | High-sensitivity quantitative analysis reveals the non-linear relationship between the dose and deposition of diphenylarsinic acid in the rat central nervous system following its subchronic exposure | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Masuda, Tomoyuki
× Masuda, Tomoyuki× Ishii, Kazuhiro× Nakayama, Tomohiro× Iwasaki, Nobuaki× Shibata, Yasuyuki× Tamaoka, Akira |
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著者別名 |
増田, 知之
× 増田, 知之 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the year 2003, the residents of Kamisu, Japan, were exposed to pentavalent organic arsenic diphenylarsinic acid (DPAA[V]) via their normal drinking water. Following the exposure, they developed cerebellar and brainstem symptoms. Although the relatively high dose of DPAA(V) is assumed to have caused their symptoms, the relationship between the exposed dose of DPAA(V) and the level of their deposition in the central nervous system (CNS) remains unclear. Using liquid chromatography–tandem mass spectrometry, we examined the deposition of DPAA(V) and its pentavalent metabolites in the CNS tissues of Crl:CD(SD) rats following the administration of DPAA(V) for 28 days. We found that the concentrations of DPAA(V) in the CNS were very high, given a dose of 5.0 mg/kg/day. However, very low concentrations of DPAA(V) were detected at a dose of 0.3 or 1.2 mg/kg/day, suggesting the absence of a linear dose-response relationship between the dose and deposition of DPAA(V). We also found that this non-linear relationship was commonly observed in various non-CNS tissues, including the excretory system. Our study showed for the first time the exact relationship between the dose and tissue deposition of the organic arsenic following its subchronic administration. | |||||
書誌情報 |
Neurotoxicology and teratology 巻 65, p. 26-33, 発行日 2017-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08920362 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1066890X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29225007 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ntt.2017.12.004 | |||||
権利 | ||||||
権利情報 | © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Elsevier |