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Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys
http://hdl.handle.net/2241/00150612
http://hdl.handle.net/2241/001506120f8b126b-a09a-45ca-b421-6e0efe546fd9
名前 / ファイル | ライセンス | アクション |
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AT_91-2799 (1.3 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-02-20 | |||||
タイトル | ||||||
タイトル | Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Masuda, Tomoyuki
× Masuda, Tomoyuki× Ishii, Kazuhiro× Seto, Yasuo× Hosoya, Tomoko× Tanaka, Ryuta× Nakayama, Tomohiro× Iwasaki, Nobuaki× Shibata, Yasuyuki× Tamaoka, Akira |
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著者別名 |
増田, 知之
× 増田, 知之× 石井, 一弘× 田中, 竜太× 玉岡, 晃 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Diphenylarsinic acid (DPAA) is an organic arsenic compound used for the synthesis of chemical weapons. We previously found that the residents of Kamisu city in Ibaraki Prefecture, Japan, were exposed to DPAA through contaminated well water in 2003. Although mounting evidence strongly suggests that their neurological symptoms were caused by DPAA, the dynamics of DPAA distribution and metabolism after ingestion by humans remain to be elucidated. To accurately predict the distribution of DPAA in the human body, we administrated DPAA (1.0 mg/kg/day) to cynomolgus monkeys (n = 28) for 28 days. The whole tissues from these monkeys were collected at 5, 29, 170, and 339 days after the last administration. The concentration of DPAA in these tissues was measured by liquid chromatography–mass spectrometry. We found that DPAA accumulated in the central nervous system tissues for a longer period than in other tissues. This finding would extend our knowledge on the distribution dynamics and metabolism of DPAA in primates, including humans. Furthermore, it may be useful for developing a treatment strategy for patients who are exposed to DPAA. | |||||
書誌情報 |
Archives of toxicology 巻 91, 号 8, p. 2799-2812, 発行日 2017-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0340-5761 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00548865 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28120037 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00204-016-1928-z | |||||
権利 | ||||||
権利情報 | © The Author(s) 2017. This article is published with open access at Springerlink.com | |||||
権利 | ||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http:// creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Springer International Publishing AG. |