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Modulation of Unfolded Protein Response by Methylmercury
http://hdl.handle.net/2241/00148394
http://hdl.handle.net/2241/001483940cca26c1-354c-4f12-bd7b-64ad8f172bc7
名前 / ファイル | ライセンス | アクション |
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BPB_40-9 (671.0 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | Modulation of Unfolded Protein Response by Methylmercury | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hiraoka, Hideki
× Hiraoka, Hideki× Nakahara, Kengo× Kaneko, Yuki× Akiyama, Shiori× Okuda, Kosaku× Iwawaki, Takao× Fujimura, Masatake× Kumagai, Yoshito× Takasugi, Nobumasa× Uehara, Takashi |
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著者別名 |
熊谷, 嘉人
× 熊谷, 嘉人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methylmercury (MeHg) results in cell death through endoplasmic reticulum (ER) stress. Previously, we reported that MeHg induces S-mercuration at cysteine 383 or 386 in protein disulfide isomerase (PDI), and this modification induces the loss of enzymatic activity. Because PDI is a key enzyme for the maturation of nascent protein harboring a disulfide bond, the disruption in PDI function by MeHg results in ER stress via the accumulation of misfolded proteins. However, the effects of MeHg on unfolded protein response (UPR) sensors and their signaling remain unclear. In the present study, we show that UPR is regulated by MeHg. We found that MeHg specifically attenuated inositol-requiring enzyme 1α (IRE1α)–x-box binding protein 1 (XBP1) branch, but not the protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcriptional factor 6 (ATF6) branches. Treatment with GSK2606414, a specific PERK inhibitor, significantly inhibited MeHg-induced cell death. These findings suggest that MeHg exquisitely regulates UPR signaling involved in cell death. | |||||
書誌情報 |
Biological & pharmaceutical bulletin 巻 40, 号 9, p. 1595-1598, 発行日 2017-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28867746 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b17-00359 | |||||
権利 | ||||||
権利情報 | © 2017 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Pharmaceutical Society of Japan |