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To assess this drug interaction, changes in prothrombin time-international normalized ratio (PT-INR) before and after tramadol coadministration were investigated in patients receiving warfarin. For this study, we examined 54 patients (male/female: 22/32, 68.4±12.7 years) who were being treated with warfarin for deep vein thrombosis, atrial fibrillation, arteriosclerosis obliterans, congestive heart failure, and other vascular diseases. Significant increases in PT-INR were observed 9.5 (1-118) d after coadministration of tramadol (1.81±0.56 vs. 2.47±1.10, p\u003c0.01). Twenty-eight patients (PT-INR increased group) with PT-INR elevation of greater than 0.5 or dose reduction of warfarin after coadministration of tramadol were compared with other groups of patients to find drug interaction risk factors. Logistic regression analysis revealed that lower levels of albumin (3.5 g/dL or less) [odds ratio (OR) 22.1; 95%CI 2.9-169.9]; lower eGFR (50 mL/min or less) (OR 7.7; 95%CI 1.4-42.0); and PT-INR before tramadol coadministration (OR 38.2; 95%CI 3.7-397.6) were characteristic of the PT-INR increased group. 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トラマドールの併用がワルファリン服用患者の PT-INR の変動に及ぼす影響
http://hdl.handle.net/2241/00147371
http://hdl.handle.net/2241/001473719963411b-8e30-4522-909a-fa2dbf02fef6
名前 / ファイル | ライセンス | アクション |
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YZ_137-8 (274.7 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-09-05 | |||||
タイトル | ||||||
タイトル | トラマドールの併用がワルファリン服用患者の PT-INR の変動に及ぼす影響 | |||||
その他のタイトル | ||||||
その他のタイトル | <Note>Effects of Tramadol Coadministration on Prothrombin Time-International Normalized Ratio in Patients Receiving Warfarin | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
細野, 智美
× 細野, 智美× 近藤, 愛子× 神林, 泰行× 本間, 真人 |
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著者別名 |
Homma, Masato
× Homma, Masato |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several case studies have reported a possible drug interaction between warfarin and tramadol where tramadol coadministration enhanced the antithrombotic effects of warfarin. To assess this drug interaction, changes in prothrombin time-international normalized ratio (PT-INR) before and after tramadol coadministration were investigated in patients receiving warfarin. For this study, we examined 54 patients (male/female: 22/32, 68.4±12.7 years) who were being treated with warfarin for deep vein thrombosis, atrial fibrillation, arteriosclerosis obliterans, congestive heart failure, and other vascular diseases. Significant increases in PT-INR were observed 9.5 (1-118) d after coadministration of tramadol (1.81±0.56 vs. 2.47±1.10, p<0.01). Twenty-eight patients (PT-INR increased group) with PT-INR elevation of greater than 0.5 or dose reduction of warfarin after coadministration of tramadol were compared with other groups of patients to find drug interaction risk factors. Logistic regression analysis revealed that lower levels of albumin (3.5 g/dL or less) [odds ratio (OR) 22.1; 95%CI 2.9-169.9]; lower eGFR (50 mL/min or less) (OR 7.7; 95%CI 1.4-42.0); and PT-INR before tramadol coadministration (OR 38.2; 95%CI 3.7-397.6) were characteristic of the PT-INR increased group. These results suggest that tramadol coadministration enhanced the antithrombotic effects of warfarin in patients with higher PT-INR, lower albumin levels and decreased renal function as the risk factors for this drug interaction. | |||||
書誌情報 |
藥學雜誌 en : Yakugaku zasshi 巻 137, 号 8, p. 999-1003, 発行日 2016-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-6903 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00241525 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28768953 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/yakushi.16-00270 | |||||
権利 | ||||||
権利情報 | © 2017 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | 公益社団法人日本薬学会 | |||||
出版者別名 | ||||||
出版者 | Pharmaceutical Society of Japan |