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Aggregative protein–polyelectrolyte complex for high-concentration formulation of protein drugs
http://hdl.handle.net/2241/00146833
http://hdl.handle.net/2241/00146833bd2a089f-a0f2-4eeb-8fd1-5d269c844b6d
名前 / ファイル | ライセンス | アクション |
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IJBM_100 (597.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-07-20 | |||||
タイトル | ||||||
タイトル | Aggregative protein–polyelectrolyte complex for high-concentration formulation of protein drugs | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kurinomaru, Takaaki
× Kurinomaru, Takaaki× Shiraki, Kentaro |
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著者別名 |
白木, 賢太郎
× 白木, 賢太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aggregative protein–polyelectrolyte complex (PPC) has been proposed as a concentrated state of protein with a great potential for biopharmaceutical application. In this review article, we introduce a unique concentration method of protein formulation using PPC for a dozen types of pharmaceutical antibodies, hormones, and enzymes. Aggregative PPC can be obtained only by mixing poly(amino acid)s with proteins under low salt concentration conditions at an ambient temperature. The aggregative PPC is in a stabilized state against shaking, heating, and oxidation. More importantly, the aggregative PPC can be fully redissolved by the addition of physiological saline without denaturation and activity loss for many proteins. In addition, the general toxicity and pharmacokinetic profiles of the aggregative PPC are identical to those of the control antibody formulation. Thus, the protein formulation produced by aggregative PPC would be applicable for biomedical use as a kind of concentrated-state protein. | |||||
書誌情報 |
International journal of biological macromolecules 巻 100, p. 11-17, 発行日 2017-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01418130 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00233999 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27287770 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijbiomac.2016.06.016 | |||||
権利 | ||||||
権利情報 | © 2016 Elsevier B.V. All rights reserved. | |||||
権利 | ||||||
権利情報 | This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | ELSEVIER |