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Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis
http://hdl.handle.net/2241/00145570
http://hdl.handle.net/2241/00145570aba96faf-4e82-4ce7-b25d-bf185ba3e895
名前 / ファイル | ライセンス | アクション |
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II_28-12 (1.3 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-03-17 | |||||
タイトル | ||||||
タイトル | Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tsurusaki, Satoshi
× Tsurusaki, Satoshi× Tahara-Hanaoka, Satoko× Shibagaki, Shohei× Miyake, Shota× Imai, Masamichi× Shibayama, Shiro× Kubo, Masato× Shibuya, Akira |
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著者別名 |
田原, 聡子
× 田原, 聡子× 渋谷, 彰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro. Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G+ neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae. Using Mas–TRECK mice, which is an MC deletion system based on il4 enhancer elements, we also demonstrated that Allergin-1 on MCs is responsible for the Pam2CSK4-induced ear swelling. These results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis. | |||||
書誌情報 |
International immunology 巻 28, 号 12, p. 605-609, 発行日 2016-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0953-8178 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10730708 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27932517 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/intimm/dxw046 | |||||
権利 | ||||||
権利情報 | © The Japanese Society for Immunology. 2016. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Oxford University Press |