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Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging
http://hdl.handle.net/2241/00145139
http://hdl.handle.net/2241/00145139361dfd65-6c86-4340-9a4e-339b35ce9e37
名前 / ファイル | ライセンス | アクション |
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COGD_38 (314.0 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-01-31 | |||||
タイトル | ||||||
タイトル | Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hayashi, Jun-Ichi
× Hayashi, Jun-Ichi× Hashizume, Osamu× Ishikawa, Kaori× Shimizu, Akinori |
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著者別名 |
石川, 香
× 石川, 香 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The mitochondria theory of aging proposes that accumulation of mitochondrial DNA (mtDNA) with pathogenic mutations, and the resultant respiration defects, are responsible not only for mitochondrial diseases but also for aging and age-associated disorders, including tumor development. This theory is partly supported by results obtained from our transmitochondrial mice (mito-mice), which harbour mtDNA with mutations that are orthologous to those found in patients with mitochondrial diseases: mito-mice express disease phenotypes only when they express respiration defects caused by accumulation of mutated mtDNA. With regard to tumor development, specific mtDNA mutations that induce reactive oxygen species (ROS) enhance malignant transformation of lung carcinoma cells to cells with high metastatic potential. However, age-associated respiration defects in elderly human fibroblasts are due not to mtDNA mutations but to epigenetic regulation of nuclear-coded genes, as indicated by the fact that normal respiratory function is restored by reprogramming of elderly fibroblasts. | |||||
書誌情報 |
Current opinion in genetics & development 巻 38, p. 63-67, 発行日 2016-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0959-437X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10879803 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27078865 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.gde.2016.03.004 | |||||
権利 | ||||||
権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier |