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Adenylation by testis-specific cytoplasmic poly(A) polymerase, PAPOLB/TPAP, is essential for spermatogenesis
http://hdl.handle.net/2241/00145099
http://hdl.handle.net/2241/00145099157f7bbf-8f1e-4a89-acae-669d4fde6da1
名前 / ファイル | ライセンス | アクション |
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JRD_62-6 (1.4 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-01-26 | |||||
タイトル | ||||||
タイトル | Adenylation by testis-specific cytoplasmic poly(A) polymerase, PAPOLB/TPAP, is essential for spermatogenesis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
KASHIWABARA, Shin-ichi
× KASHIWABARA, Shin-ichi× TSURUTA, Satsuki× OKADA, Keitaro× YAMAOKA, Yutaro× BABA, Tadashi |
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著者別名 |
柏原, 真一
× 柏原, 真一× 馬場, 忠 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The testis-specific cytoplasmic poly(A) polymerase PAPOLB/TPAP is essential for spermatogenesis. Although this enzyme is responsible for poly(A) tail extension of a subset of mRNAs in round spermatids, the stability and translational efficiency of these mRNAs are unaffected by the absence of PAPOLB. To clarify the functional importance of this enzyme’s adenylation activity, we produced PAPOLB-null mice expressing a polyadenylation-defective PAPOLB mutant (PAPOLBD114A), in which the catalytic Asp at residue 114 was mutated to Ala. Introducing PAPOLBD114A failed to rescue PAPOLB-null phenotypes, such as reduced expression of haploid-specific mRNAs, spermiogenesis arrest, and male infertility. These results suggest that PAPOLB regulates spermatogenesis through its adenylation activity. | |||||
書誌情報 |
The Journal of reproduction and development 巻 62, 号 6, p. 607-614, 発行日 2016 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0916-8818 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10936678 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27647534 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1262/jrd.2016-116 | |||||
権利 | ||||||
権利情報 | ©2016 by the Society for Reproduction and Development | |||||
権利 | ||||||
権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/4.0/>. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Society Reproduction and Development |