WEKO3
アイテム
{"_buckets": {"deposit": "1453da0d-e4cd-4d75-a9ef-74b0bb84d06f"}, "_deposit": {"id": "39956", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "39956"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00039956", "sets": ["2204", "5555"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "20", "bibliographicPageEnd": "3231", "bibliographicPageStart": "3225", "bibliographicVolumeNumber": "122", "bibliographic_titles": [{"bibliographic_title": "Cancer"}]}]}, "item_5_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "石川, 仁"}], "nameIdentifiers": [{"nameIdentifier": "157114", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70344918", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000070344918"}, {"nameIdentifier": "0000003133", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000003133"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND\nWhether biochemical recurrence (BR) is a significant predictive factor of mortality after definitive radiation therapy for prostate cancer remains unknown. The aim of the current study was to investigate the relation between BR and overall mortality (OAM) in high-risk prostate cancer patients who were treated with carbon-ion radiotherapy (CIRT) and had long-term follow-up in 2 prospective trials.\n\nMETHODS\nIn the 2 phase 2 clinical trials, which involved 466 prostate cancer patients who received 63.0 to 66.0 Gy of CIRT (relative biological effect) in 20 fractions between 2000 and 2007, 324 patients who were deemed to be at high risk on the basis of the modified D\u0027Amico classification criteria and received CIRT along with androgen-deprivation therapy (ADT) were examined. The OAM rate was adjusted for the ADT duration, and multivariate analyses using a Cox proportional hazards model were performed for OAM with BR as a time-dependent covariate.\n\nRESULTS\nThe median follow-up period was 107.4 months, and the 5- and 10-year OAM rates after adjustments for the ADT duration were 7.0% (95% confidence interval [CI], 4.0%-9.4%) and 23.9% (95% CI, 16.4%-26.2%), respectively. A multivariate analysis revealed that the presence of BR (hazard ratio, 2.82; 95% Cl, 1.57-5.08; P = .001) was one of the predictive factors for OAM. On the other hand, the duration of ADT had no impact on OAM.\n\nCONCLUSIONS\nBR after CIRT combined with ADT is an independent predictive factor for OAM in high-risk prostate cancer patients. The results of this study could be applied to other high-dose radiation therapies.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "27351298", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/cncr.30050", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made."}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0008-543X", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00598342", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "医学", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kasuya, Goro"}], "nameIdentifiers": [{"nameIdentifier": "155842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "155843", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuji, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "155844", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nomiya, Takuma"}], "nameIdentifiers": [{"nameIdentifier": "155845", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Makishima, Hirokazu"}], "nameIdentifiers": [{"nameIdentifier": "155846", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamada, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "155847", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akakura, Koichiro"}], "nameIdentifiers": [{"nameIdentifier": "155848", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Hiroyoshi"}], "nameIdentifiers": [{"nameIdentifier": "155849", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimazaki, Jun"}], "nameIdentifiers": [{"nameIdentifier": "155850", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haruyama, Yasuo"}], "nameIdentifiers": [{"nameIdentifier": "155851", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobashi, Gen"}], "nameIdentifiers": [{"nameIdentifier": "155852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujii, Hirohiko"}], "nameIdentifiers": [{"nameIdentifier": "155853", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-12-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Cancer_122-20.pdf", "filesize": [{"value": "103.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 103300.0, "url": {"label": "Cancer_122-20", "url": "https://tsukuba.repo.nii.ac.jp/record/39956/files/Cancer_122-20.pdf"}, "version_id": "e7755a24-6be4-4214-b14e-04853464c1cc"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Significant impact of biochemical recurrence on overall mortality in patients with high-risk prostate cancer after carbon-ion radiotherapy combined with androgen deprivation therapy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Significant impact of biochemical recurrence on overall mortality in patients with high-risk prostate cancer after carbon-ion radiotherapy combined with androgen deprivation therapy"}]}, "item_type_id": "5", "owner": "1", "path": ["2204", "5555"], "permalink_uri": "http://hdl.handle.net/2241/00144724", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-12-26"}, "publish_date": "2016-12-26", "publish_status": "0", "recid": "39956", "relation": {}, "relation_version_is_last": true, "title": ["Significant impact of biochemical recurrence on overall mortality in patients with high-risk prostate cancer after carbon-ion radiotherapy combined with androgen deprivation therapy"], "weko_shared_id": 5}
Significant impact of biochemical recurrence on overall mortality in patients with high-risk prostate cancer after carbon-ion radiotherapy combined with androgen deprivation therapy
http://hdl.handle.net/2241/00144724
http://hdl.handle.net/2241/00144724a166bc6b-9585-4e4e-b857-8984b3f6241a
名前 / ファイル | ライセンス | アクション |
---|---|---|
Cancer_122-20 (103.3 kB)
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-12-26 | |||||
タイトル | ||||||
タイトル | Significant impact of biochemical recurrence on overall mortality in patients with high-risk prostate cancer after carbon-ion radiotherapy combined with androgen deprivation therapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kasuya, Goro
× Kasuya, Goro× Ishikawa, Hitoshi× Tsuji, Hiroshi× Nomiya, Takuma× Makishima, Hirokazu× Kamada, Tadashi× Akakura, Koichiro× Suzuki, Hiroyoshi× Shimazaki, Jun× Haruyama, Yasuo× Kobashi, Gen× Tsujii, Hirohiko |
|||||
著者別名 |
石川, 仁
× 石川, 仁 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND Whether biochemical recurrence (BR) is a significant predictive factor of mortality after definitive radiation therapy for prostate cancer remains unknown. The aim of the current study was to investigate the relation between BR and overall mortality (OAM) in high-risk prostate cancer patients who were treated with carbon-ion radiotherapy (CIRT) and had long-term follow-up in 2 prospective trials. METHODS In the 2 phase 2 clinical trials, which involved 466 prostate cancer patients who received 63.0 to 66.0 Gy of CIRT (relative biological effect) in 20 fractions between 2000 and 2007, 324 patients who were deemed to be at high risk on the basis of the modified D'Amico classification criteria and received CIRT along with androgen-deprivation therapy (ADT) were examined. The OAM rate was adjusted for the ADT duration, and multivariate analyses using a Cox proportional hazards model were performed for OAM with BR as a time-dependent covariate. RESULTS The median follow-up period was 107.4 months, and the 5- and 10-year OAM rates after adjustments for the ADT duration were 7.0% (95% confidence interval [CI], 4.0%-9.4%) and 23.9% (95% CI, 16.4%-26.2%), respectively. A multivariate analysis revealed that the presence of BR (hazard ratio, 2.82; 95% Cl, 1.57-5.08; P = .001) was one of the predictive factors for OAM. On the other hand, the duration of ADT had no impact on OAM. CONCLUSIONS BR after CIRT combined with ADT is an independent predictive factor for OAM in high-risk prostate cancer patients. The results of this study could be applied to other high-dose radiation therapies. |
|||||
書誌情報 |
Cancer 巻 122, 号 20, p. 3225-3231, 発行日 2016-10 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0008-543X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00598342 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27351298 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/cncr.30050 | |||||
権利 | ||||||
権利情報 | © 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley |