WEKO3
アイテム
{"_buckets": {"deposit": "a2aa9de8-2964-4ec2-96da-9342364c8a4a"}, "_deposit": {"id": "38455", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "38455"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00038455", "sets": ["811", "5303"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "4984597", "bibliographicVolumeNumber": "2016", "bibliographic_titles": [{"bibliographic_title": "Oxidative medicine and cellular longevity"}]}]}, "item_5_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "長崎, 幸夫"}], "nameIdentifiers": [{"nameIdentifier": "357", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90198309", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000090198309"}, {"nameIdentifier": "0000000786", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000000786"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The purpose of this study was to evaluate the hepatoprotective effect of an antioxidative nanoparticle (RNPN) recently developed against APAP-induced hepatotoxicity in mice. The effects of oral administration of RNPN to APAP-treated mice were assessed for various biochemical liver function parameters: alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, prothrombin time, and serum albumin (ALB) level. The treatment effects were assessed in terms of free radical parameters: malondialdehyde (MDA) accumulation, glutathione peroxidase (GPx) activity, % inhibition of superoxide anion (O2−∙), and histopathological examination. The N-acetylcysteine (NAC)-treated group exhibited an enhanced prothrombin time relative to the control group, while RNPN did not prolong prothrombin time. The RNPN-treated animals exhibited lower levels of ALT, AST, and ALP, while increased ALB levels were measured in these animals compared to those in the other groups. The RNPN-treated animals furthermore exhibited improved MDA levels, GPx activity, and % inhibition of O2−∙, which relate to oxidative damage. Histological staining of liver tissues from RNPN-treated animals did not reveal any microscopic changes relative to the other groups. The findings of this study suggest that RNPN possesses effective hepatoprotective properties and does not exhibit the notable adverse effects associated with NAC treatment.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Hindawi Publishing Corporation"}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1155/2016/4984597", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2016 Phetcharat Boonruamkaew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1942-0900", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12489832", "subitem_source_identifier_type": "NCID"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Boonruamkaew, Phetcharat"}], "nameIdentifiers": [{"nameIdentifier": "139806", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chonpathompikunlert, Pennapa"}], "nameIdentifiers": [{"nameIdentifier": "139807", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagasaki, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "139808", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-07-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "OMCL_2016-4984597.pdf", "filesize": [{"value": "3.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 3800000.0, "url": {"label": "OMCL_2016-4984597", "url": "https://tsukuba.repo.nii.ac.jp/record/38455/files/OMCL_2016-4984597.pdf"}, "version_id": "4090959d-a73e-47da-88ec-4c9ee510bbe0"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice"}]}, "item_type_id": "5", "owner": "1", "path": ["811", "5303"], "permalink_uri": "http://hdl.handle.net/2241/00143128", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-07-07"}, "publish_date": "2016-07-07", "publish_status": "0", "recid": "38455", "relation": {}, "relation_version_is_last": true, "title": ["Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice"], "weko_shared_id": 5}
Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice
http://hdl.handle.net/2241/00143128
http://hdl.handle.net/2241/00143128ef38d371-04ac-49a1-9688-580e4f01c02b
名前 / ファイル | ライセンス | アクション |
---|---|---|
OMCL_2016-4984597 (3.8 MB)
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-07-07 | |||||
タイトル | ||||||
タイトル | Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Boonruamkaew, Phetcharat
× Boonruamkaew, Phetcharat× Chonpathompikunlert, Pennapa× Nagasaki, Yukio |
|||||
著者別名 |
長崎, 幸夫
× 長崎, 幸夫 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was to evaluate the hepatoprotective effect of an antioxidative nanoparticle (RNPN) recently developed against APAP-induced hepatotoxicity in mice. The effects of oral administration of RNPN to APAP-treated mice were assessed for various biochemical liver function parameters: alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, prothrombin time, and serum albumin (ALB) level. The treatment effects were assessed in terms of free radical parameters: malondialdehyde (MDA) accumulation, glutathione peroxidase (GPx) activity, % inhibition of superoxide anion (O2−∙), and histopathological examination. The N-acetylcysteine (NAC)-treated group exhibited an enhanced prothrombin time relative to the control group, while RNPN did not prolong prothrombin time. The RNPN-treated animals exhibited lower levels of ALT, AST, and ALP, while increased ALB levels were measured in these animals compared to those in the other groups. The RNPN-treated animals furthermore exhibited improved MDA levels, GPx activity, and % inhibition of O2−∙, which relate to oxidative damage. Histological staining of liver tissues from RNPN-treated animals did not reveal any microscopic changes relative to the other groups. The findings of this study suggest that RNPN possesses effective hepatoprotective properties and does not exhibit the notable adverse effects associated with NAC treatment. | |||||
書誌情報 |
Oxidative medicine and cellular longevity 巻 2016, p. 4984597, 発行日 2016 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1942-0900 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12489832 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2016/4984597 | |||||
権利 | ||||||
権利情報 | © 2016 Phetcharat Boonruamkaew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation |