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Posttreatment human papillomavirus testing for residual or recurrent high-grade cervical intraepithelial neoplasia: a pooled analysis
http://hdl.handle.net/2241/00143030
http://hdl.handle.net/2241/00143030a60bc7e7-f7ee-4e38-be3d-bec0a8a642a3
名前 / ファイル | ライセンス | アクション |
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JGO_27-1 (328.1 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-06-28 | |||||
タイトル | ||||||
タイトル | Posttreatment human papillomavirus testing for residual or recurrent high-grade cervical intraepithelial neoplasia: a pooled analysis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Onuki, Mamiko
× Onuki, Mamiko× Matsumoto, Koji× Sakurai, Manabu× Ochi, Hiroyuki× Minaguchi, Takeo× Satoh, Toyomi× Yoshikawa, Hiroyuki |
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著者別名 |
小貫, 麻美子
× 小貫, 麻美子× 櫻井, 学× 越智, 寛幸× 水口, 剛雄× 佐藤, 豊実 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective We conducted a pooled analysis of published studies to compare the performance of human papillomavirus (HPV) testing and cytology in detecting residual or recurrent diseases after treatment for cervical intraepithelial neoplasia grade 2 or 3 (CIN 2/3). Methods Source articles presenting data on posttreatment HPV testing were identified from the National Library of Medicine (PubMed) database. We included 5,319 cases from 33 articles published between 1996 and 2013. Results The pooled sensitivity of high-risk HPV testing (0.92; 95% confidence interval [CI], 0.90 to 0.94) for detecting posttreatment CIN 2 or worse (CIN 2+) was much higher than that of cytology (0.76; 95% CI, 0.71 to 0.80). Co-testing of HPV testing and cytology maximized the sensitivity (0.93; 95% CI, 0.87 to 0.96), while HPV genotyping (detection of the same genotype between pre- and posttreatments) did not improve the sensitivity (0.89; 95% CI, 0.82 to 0.94) compared with high-risk HPV testing alone. The specificity of high-risk HPV testing (0.83; 95% CI, 0.82 to 0.84) was similar to that of cytology (0.85; 95% CI, 0.84 to 0.87) and HPV genotyping (0.83; 95% CI, 0.81 to 0.85), while co-testing had reduced specificity (0.76; 95% CI, 0.75 to 0.78). For women with positive surgical margins, high-risk HPV testing provided remarkable risk discrimination between test-positives and test-negatives (absolute risk of residual CIN 2+ 74.4% [95% CI, 64.0 to 82.6] vs. 0.8% [95% CI, 0.15 to 4.6]; p<0.001). Conclusion Our findings recommend the addition of high-risk HPV testing, either alone or in conjunction with cytology, to posttreatment surveillance strategies. HPV testing can identify populations at greatest risk of posttreatment CIN 2+ lesions, especially among women with positive section margins. |
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書誌情報 |
Journal of gynecologic oncology 巻 27, 号 1, p. e3, 発行日 2016-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2005-0380 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26463429 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3802/jgo.2016.27.e3 | |||||
権利 | ||||||
権利情報 | © 2016. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology | |||||
権利 | ||||||
権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Asian Society of Gynecologic Oncology | |||||
出版者 | ||||||
出版者 | Korean Society of Gynecologic Oncology |