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Correlations of survival with progression-free survival, response rate, and disease control rate in advanced biliary tract cancer: a meta-analysis of randomised trials of first-line chemotherapy
http://hdl.handle.net/2241/00142061
http://hdl.handle.net/2241/001420612e9545ef-e891-4b37-b20b-56f4135ae668
名前 / ファイル | ライセンス | アクション |
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BJC 114-8 (775.1 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-06-10 | |||||
タイトル | ||||||
タイトル | Correlations of survival with progression-free survival, response rate, and disease control rate in advanced biliary tract cancer: a meta-analysis of randomised trials of first-line chemotherapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yamamoto, Yoshiyuki
× Yamamoto, Yoshiyuki× Kobayashi, Mariko× Sugaya, Akinori× Endo, Shinji× Moriwaki, Toshikazu× Gosho, Masahiko× Hyodo, Ichinosuke |
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著者別名 |
五所, 正彦
× 五所, 正彦× 森脇, 俊和× 兵頭, 一之介 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The need to promote novel drug development for advanced biliary tract cancer (ABTC) has emphasised the importance of determining whether various efficacy end points can act as surrogates for overall survival (OS). Methods: We conducted a literature search of randomised trials of first-line chemotherapy for ABTC and investigated correlations between efficacy end points and OS using weighted linear regression analysis. The ratios of the median OS, median progression-free survival (PFS), response rate, and disease control rate in each trial were used to summarise treatment effects. The surrogate threshold effect (STE), which was the minimum treatment effect on PFS required to predict a non-zero treatment effect on OS, was calculated. Results: Seventeen randomised trials with 36 treatment arms were identified, and a sample size of 2148 patients with 19 paired arms was analysed. The strongest correlation between all evaluated efficacy end points was observed between median OS and median PFS ratios (r2=0.66). In trials with gemcitabine-containing therapies and targeted agents, the r2-values were 0.78. The STE was estimated at 0.83 for all trials and 0.81 for trials with gemcitabine-containing therapies, and was not calculated for trials with targeted agents. Conclusions: The median PFS ratio correlated well with the median OS ratio, and may be useful for planning a clinical trial for novel drug development. |
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書誌情報 |
British journal of cancer 巻 114, p. 881-888, 発行日 2016-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0007-0920 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00574355 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/bjc.2016.83 | |||||
権利 | ||||||
権利情報 | © 2016 Cancer Research UK | |||||
権利 | ||||||
権利情報 | This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 4.0 International License. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-sa/4.0/ | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Nature Publishing Group |