WEKO3
アイテム
{"_buckets": {"deposit": "94fe2bd0-f300-4660-a8a6-38d33c87fe3f"}, "_deposit": {"id": "38218", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "38218"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00038218", "sets": ["306", "5134"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "289", "bibliographicPageStart": "276", "bibliographicVolumeNumber": "23", "bibliographic_titles": [{"bibliographic_title": "Current medicinal chemistry"}]}]}, "item_5_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "白木, 賢太郎"}], "nameIdentifiers": [{"nameIdentifier": "79", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90334797", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000090334797"}, {"nameIdentifier": "0000000710", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000000710"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A polyelectrolyte is a polymer composed of repeating units of an electrolyte group that enables reversible complex formation with proteins in aqueous solutions. This review introduces “wrap-and-strip” technology of protein–polyelectrolyte complex (PPC) by noncovalent interaction. Storage: protein is stabilized against physical and chemical stresses. Enrichment: precipitation through PPC can be used as an enrichment method without irreversible unfolding. Catalytic activity switch: a complementary charged pair of polyelectrolytes functions as a reversible enzyme activity switch. Hyperactivation: a specific combination of a polyelectrolyte and substrate enhances enzyme activity by one order of magnitude compared with an enzyme alone. Stabilization: PPC increases protein stability against chemical and physical stresses, such as covalently modified polyethylene glycosylated protein. Simple PPC-based technology can expand the applicable fields of soluble proteins in aqueous solutions. - See more at: http://www.eurekaselect.com/137346/article#sthash.G09jICYk.dpuf", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Bentham Science Publishers"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "26630921", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2174/0929867323666151127201126", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article\u0026doi=10.2174/0929867323666151127201126."}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0929-8673", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11015821", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "化学", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shiraki, Kentaro"}], "nameIdentifiers": [{"nameIdentifier": "131827", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurinomaru, Takaaki"}], "nameIdentifiers": [{"nameIdentifier": "131828", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomita, Shunsuke"}], "nameIdentifiers": [{"nameIdentifier": "131829", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CMC_23-3.pdf", "filesize": [{"value": "675.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 675000.0, "url": {"label": "CMC_23-3", "url": "https://tsukuba.repo.nii.ac.jp/record/38218/files/CMC_23-3.pdf"}, "version_id": "7847eeaa-0a3a-48d5-b875-6776dfe19ae0"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Wrap-and-Strip Technology of Protein–Polyelectrolyte Complex for Biomedical Application", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Wrap-and-Strip Technology of Protein–Polyelectrolyte Complex for Biomedical Application"}]}, "item_type_id": "5", "owner": "1", "path": ["306", "5134"], "permalink_uri": "http://hdl.handle.net/2241/00141975", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-06-02"}, "publish_date": "2016-06-02", "publish_status": "0", "recid": "38218", "relation": {}, "relation_version_is_last": true, "title": ["Wrap-and-Strip Technology of Protein–Polyelectrolyte Complex for Biomedical Application"], "weko_shared_id": 5}
Wrap-and-Strip Technology of Protein–Polyelectrolyte Complex for Biomedical Application
http://hdl.handle.net/2241/00141975
http://hdl.handle.net/2241/0014197592eca463-d10b-4ae6-a94f-4d5698365f66
名前 / ファイル | ライセンス | アクション |
---|---|---|
CMC_23-3 (675.0 kB)
|
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-06-02 | |||||
タイトル | ||||||
タイトル | Wrap-and-Strip Technology of Protein–Polyelectrolyte Complex for Biomedical Application | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Shiraki, Kentaro
× Shiraki, Kentaro× Kurinomaru, Takaaki× Tomita, Shunsuke |
|||||
著者別名 |
白木, 賢太郎
× 白木, 賢太郎 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A polyelectrolyte is a polymer composed of repeating units of an electrolyte group that enables reversible complex formation with proteins in aqueous solutions. This review introduces “wrap-and-strip” technology of protein–polyelectrolyte complex (PPC) by noncovalent interaction. Storage: protein is stabilized against physical and chemical stresses. Enrichment: precipitation through PPC can be used as an enrichment method without irreversible unfolding. Catalytic activity switch: a complementary charged pair of polyelectrolytes functions as a reversible enzyme activity switch. Hyperactivation: a specific combination of a polyelectrolyte and substrate enhances enzyme activity by one order of magnitude compared with an enzyme alone. Stabilization: PPC increases protein stability against chemical and physical stresses, such as covalently modified polyethylene glycosylated protein. Simple PPC-based technology can expand the applicable fields of soluble proteins in aqueous solutions. - See more at: http://www.eurekaselect.com/137346/article#sthash.G09jICYk.dpuf | |||||
書誌情報 |
Current medicinal chemistry 巻 23, 号 3, p. 276-289, 発行日 2016-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0929-8673 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11015821 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26630921 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2174/0929867323666151127201126 | |||||
権利 | ||||||
権利情報 | The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/0929867323666151127201126. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Bentham Science Publishers |