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An actin–myosin-II interaction is involved in maintaining the contractile ring in fission yeast
http://hdl.handle.net/2241/00127733
http://hdl.handle.net/2241/0012773300a368dc-ec6a-49c5-8104-99213dc0e4cb
名前 / ファイル | ライセンス | アクション |
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JCS_128-15 (3.9 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2015-10-02 | |||||
タイトル | ||||||
タイトル | An actin–myosin-II interaction is involved in maintaining the contractile ring in fission yeast | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Takaine, Masak
× Takaine, Masak× Numata, Osamu× Nakano, Kentaro |
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著者別名 |
沼田, 治
× 沼田, 治× 中野, 賢太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The actomyosin-based contractile ring, which assembles at the cell equator, maintains its circularity during cytokinesis in many eukaryotic cells, ensuring its efficient constriction. Although consistent maintenance of the ring is one of the mechanisms underpinning cytokinesis, it has not yet been fully addressed. We here investigated the roles of fission yeast myosin-II proteins [Myo2 and Myo3 (also known as Myp2)] in ring maintenance during cytokinesis, with a focus on Myo3. A site-directed mutational analysis showed that the motor properties of Myo3 were involved in its accumulation in the contractile ring. The assembled ring was often deformed and not properly maintained under conditions in which the activities of myosin-II proteins localizing to the contractile ring were decreased, leading to inefficient cell division. Moreover, Myo3 appeared to form motile clusters on the ring. We propose that large assemblies of myosin-II proteins consolidate the contractile ring by continuously binding to F-actin in the ring, thereby contributing to its maintenance. | |||||
書誌情報 |
Journal of cell science 巻 128, 号 15, p. 2903-2918, 発行日 2015-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-9533 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1477-9137 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11720335 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26092938 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1242/jcs.171264 | |||||
権利 | ||||||
権利情報 | © 2015. Published by The Company of Biologists Ltd | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | The Company of Biologists Ltd |