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Ceramide/sphingomyelin cycle involvement in gentamicin-induced cochlear hair cell death
http://hdl.handle.net/2241/00124527
http://hdl.handle.net/2241/001245278ccdcb4a-6901-4f6a-8e07-25ec8f7503d5
名前 / ファイル | ライセンス | アクション |
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AT_89-3 (1.9 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2015-05-13 | |||||
タイトル | ||||||
タイトル | Ceramide/sphingomyelin cycle involvement in gentamicin-induced cochlear hair cell death | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Chi, Le Nguyen Uyen
× Chi, Le Nguyen Uyen× Tabuchi, Keiji× Nakamagoe, Mariko× Nakayama, Masahiro× Nishimura, Bungo× Hara, Akira |
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著者別名 |
田渕, 経司
× 田渕, 経司× 西村, 文吾× 原, 晃 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ceramide, a sphingolipid metabolite, regulates diverse cellular processes including apoptosis, cell senescence, the cell cycle, and cellular differentiation. Exogenously administered ceramide reportedly increased cochlear hair cell death due to gentamicin-induced ototoxicity. Ceramide is mainly generated via a ceramide/sphingomyelin cycle by sphingomyelinase and sphingomyelin synthase or via de novo synthesis by serine palmitoyltransferase and ceramide synthase. This study was designed to investigate the possible involvement of neutral sphingomyelinase, sphingomyelin synthase, or serine palmitoyltransferase in hair cell death due to gentamicin. The basal turns of the organ of Corti of Sprague–Dawley rats were dissected on postnatal days 3–5. Cochlear cultures were exposed to media containing 35 μM gentamicin for 48 h to assess the effects of GW4869 (a neutral sphingomyelinase inhibitor), 2-hydroxyoleic acid (a sphingomyelin synthase activator), and myriocin (a serine palmitoyltransferase inhibitor). Hair cell loss was significantly decreased in the presence of GW4869 or 2-hydroxyoleic acid. Myriocin had no significant effects against gentamicin-induced hair cell loss. In addition, neutral sphingomyelinase was activated by gentamicin exposure. The present findings strongly suggest that the ceramide/sphingomyelin cycle plays an important role in the protection of hair cells against gentamicin-induced ototoxicity. | |||||
書誌情報 |
Archives of toxicology 巻 89, 号 3, p. 415-421, 発行日 2015-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0340-5761 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00548865 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24798086 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00204-014-1259-x | |||||
権利 | ||||||
権利情報 | © Springer-Verlag Berlin Heidelberg 2014 | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Springer Berlin Heidelberg |