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Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background
http://hdl.handle.net/2241/00123039
http://hdl.handle.net/2241/00123039f4381e24-e03a-45d5-9721-af9c91885b8c
名前 / ファイル | ライセンス | アクション |
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MI_63-2 (1.8 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2015-01-29 | |||||
タイトル | ||||||
タイトル | Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kurita, Naoki
× Kurita, Naoki× Honda, Shin-ichiro× Shibuya, Akira |
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著者別名 |
栗田, 尚樹
× 栗田, 尚樹× 渋谷, 彰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Fcα/μR (CD351) is an Fc receptor for both IgA and IgM, which is abundantly expressed in the small intestine. However, the role of Fcα/μR in the intestinal tissue is largely unknown. Here, we found that Fcα/μR is highly expressed on follicular dendritic cells (FDCs) in Peyer's patches (PP) in the small intestine. Fcα/μR-deficient mice on the (129 x C57BL/6) F1 background showed increased serum, but not fecal, IgA level in response to gut-oriented antigens. IgA+ B cells were increased in PP, but not in the lamina propria, of Fcα/μR-deficient mice, which was attenuated after reduction of commensal microbiota by oral treatment with antibiotics. Analyses of bone marrow chimeric mice, in which either FDCs or blood cells or both lack the expression of Fcα/μR, suggested that FDCs, but not blood cells, were responsible for the increased serum IgA concentration in Fcα/μR-deficient mice. Moreover, Fcα/μR-deficient mice showed enhanced germinal center formation against commensal microbiota in PP. Thus, serum IgA production against gut-oriented antigens is negatively regulated by Fcα/μR on FDCs in the F1 mice. | |||||
書誌情報 |
Molecular immunology 巻 63, 号 2, p. 367-372, 発行日 2015-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0161-5890 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00307483 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 25282043 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.molimm.2014.09.008 | |||||
権利 | ||||||
権利情報 | © 2014 Elsevier Ltd. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Molecular immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular immunology, 63, 2, 2015, doi:10.1016/j.molimm.2014.09.008 | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier |