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Suppression of NSAID-induced small intestinal inflammation by orally administered redox nanoparticles
http://hdl.handle.net/2241/119975
http://hdl.handle.net/2241/119975e87cdff3-a618-4f40-8d55-2e26a7a21a56
名前 / ファイル | ライセンス | アクション |
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BIOMAT_34-33.pdf (5.6 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2013-11-06 | |||||
タイトル | ||||||
タイトル | Suppression of NSAID-induced small intestinal inflammation by orally administered redox nanoparticles | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sha, Sha
× Sha, Sha× Vong, Long Binh× Chonpathompikunlert, Pennapa× Yoshitomi, Toru× Matsui, Hirofumi× Nagasaki, Yukio |
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著者別名 |
松井, 裕史
× 松井, 裕史× 長崎, 幸夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Patients regularly taking non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (IND) have a risk of small intestinal injuries. In this study, we have developed an oral nanotherapeutics by using a redox nanoparticle (RNPO), which is prepared by self-assembly of an amphiphilic block copolymer that possesses nitroxide radicals as side chains of hydrophobic segment via ether linkage, to reduce inflammation in mice with IND-induced small intestinal injury. The localization and accumulation of RNPO in the small intestine were determined using fluorescent-labeled RNPO and electron spin resonance. After oral administration, the accumulation of RNPO in both the jejunum and ileum tissues was about 40 times higher than those of low-molecular-weight nitroxide radical compounds, and RNPO was not absorbed into the bloodstream via the mesentery, thereby avoiding the adverse effects of nitroxide radicals in the entire body. RNPO remarkably suppressed inflammatory mediators such as myeloperoxidase, superoxide anion, and malondialdehyde in the small intestines of IND-treated mice. Compared to low-molecular-weight nitroxide radical compounds, RNPO also significantly increased the survival rate of mice treated daily with IND. On the basis of these results, RNPO is promising as a nanotherapeutics for treatment of inflammation in the small intestine of patients receiving NSAIDs. | |||||
書誌情報 |
Biomaterials 巻 34, 号 33, p. 8393-8400, 発行日 2013-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0142-9612 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00110092 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 23896000 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.biomaterials.2013.06.032 | |||||
権利 | ||||||
権利情報 | © 2013 Elsevier Ltd. NOTICE: this is the author's version of a work that was accepted for publication in Biomaterials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterials, Volume 34 Issue 33 2013. http://dx.doi.org/10.1016/j.biomaterials.2013.06.032 | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/119975 | |||||
識別子タイプ | HDL |