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The attenuation of this increase may be associated with the pain relief induced by NMDA receptor antagonism. We tested the hypothesis that magnesium sulfate, an NMDA receptor antagonist, attenuates tourniquet pain.\nMethods\n\nTwenty-four healthy volunteers were randomly assigned to four groups (n = 6 each): control (normal saline), M1 (magnesium, 1 g), M2 (magnesium, 2 g), and M4 (magnesium, 4 g). Normal saline or magnesium solution was given intravenously over a 15-min period, in a double-blind fashion, before tourniquet inflation, which was continued for 60 min or until the “pain score” (0 = no pain, 100 = highest tolerable pain) reached 100. Pain scores were recorded before and every 5 min during tourniquet inflation. 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The area under the curve for pain scores in the M4 group was significantly smaller than the areas in the other groups.\nConclusion\n\nMagnesium sulfate, 4 g, significantly attenuated tourniquet pain in healthy awake volunteers, suggesting that NMDA receptor activation is involved in tourniquet pain.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/119165"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "23053464", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s00540-012-1493-4", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "©Japanese Society of Anesthesiologists 2012 The original publication is available at www.springerlink.com"}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0913-8668", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10852931", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "医学", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Satsumae, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "100141", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaguchi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "100142", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inomata, Shinichi"}], "nameIdentifiers": [{"nameIdentifier": "100143", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "100144", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JA_27-2.pdf", "filesize": [{"value": "392.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 392800.0, "url": {"label": "JA_27-2.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/28948/files/JA_27-2.pdf"}, "version_id": "07d71aea-db62-4e0a-a753-02490a812b31"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Magnesium sulfate attenuates tourniquet pain in healthy volunteers", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Magnesium sulfate attenuates tourniquet pain in healthy volunteers"}]}, "item_type_id": "5", "owner": "1", "path": ["1504", "2193", "1505", "2038"], "permalink_uri": "http://hdl.handle.net/2241/119165", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-05-17"}, "publish_date": "2013-05-17", "publish_status": "0", "recid": "28948", "relation": {}, "relation_version_is_last": true, "title": ["Magnesium sulfate attenuates tourniquet pain in healthy volunteers"], "weko_shared_id": 5}
Magnesium sulfate attenuates tourniquet pain in healthy volunteers
http://hdl.handle.net/2241/119165
http://hdl.handle.net/2241/119165149a4780-d20f-4cbc-be31-7f307698b416
名前 / ファイル | ライセンス | アクション |
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JA_27-2.pdf (392.8 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2013-05-17 | |||||
タイトル | ||||||
タイトル | Magnesium sulfate attenuates tourniquet pain in healthy volunteers | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Satsumae, Tsuyoshi
× Satsumae, Tsuyoshi× Yamaguchi, Hiroshi× Inomata, Shinichi× Tanaka, Makoto |
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著者別名 |
左津前, 剛
× 左津前, 剛× 猪股, 伸一× 田中, 誠 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose Preoperative administration of an N-methyl-d-aspartate (NMDA) receptor antagonist has been shown to attenuate tourniquet-induced blood pressure increase under general anesthesia, suggesting that the mechanism of this blood pressure increase includes NMDA receptor activation. The attenuation of this increase may be associated with the pain relief induced by NMDA receptor antagonism. We tested the hypothesis that magnesium sulfate, an NMDA receptor antagonist, attenuates tourniquet pain. Methods Twenty-four healthy volunteers were randomly assigned to four groups (n = 6 each): control (normal saline), M1 (magnesium, 1 g), M2 (magnesium, 2 g), and M4 (magnesium, 4 g). Normal saline or magnesium solution was given intravenously over a 15-min period, in a double-blind fashion, before tourniquet inflation, which was continued for 60 min or until the “pain score” (0 = no pain, 100 = highest tolerable pain) reached 100. Pain scores were recorded before and every 5 min during tourniquet inflation. If subjects reported a pain score of 100 before the end of the 60-min period, we adopted a pain score of 100 for the remaining period. Results The duration of tourniquet inflation in the M4 group was significantly longer than that in the control group (54.3 ± 8.3 vs. 42.9 ± 9.9 min, P = 0.03). Pain scores in the M4 group were significantly lower than those in the control group from 10 through 50 min after the start of tourniquet inflation. The area under the curve for pain scores in the M4 group was significantly smaller than the areas in the other groups. Conclusion Magnesium sulfate, 4 g, significantly attenuated tourniquet pain in healthy awake volunteers, suggesting that NMDA receptor activation is involved in tourniquet pain. |
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書誌情報 |
Journal of anesthesia 巻 27, 号 2, p. 231-235, 発行日 2013-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0913-8668 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10852931 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 23053464 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00540-012-1493-4 | |||||
権利 | ||||||
権利情報 | ©Japanese Society of Anesthesiologists 2012 The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Springer | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/119165 | |||||
識別子タイプ | HDL |