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Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
http://hdl.handle.net/2241/117846
http://hdl.handle.net/2241/117846919ffe76-08a5-4e09-bf23-621ba014cadc
名前 / ファイル | ライセンス | アクション |
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BMC_20-19.pdf (593.0 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-11-12 | |||||
タイトル | ||||||
タイトル | Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hayakawa, Ichiro
× Hayakawa, Ichiro× Ikedo, Akiyuki× Chinen, Takumi× Usui, Takeo× 木越, 英夫 |
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著者別名 |
早川, 一郎
× 早川, 一郎× 臼井, 健郎× 木越, 英夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies. | |||||
書誌情報 |
Bioorganic & medicinal chemistry 巻 20, 号 19, p. 5745-5756, 発行日 2012-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0968-0896 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10938083 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22921744 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bmc.2012.08.005 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Ltd. NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic & medicinal chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, 20(19),2012 DOI:10.1016/j.bmc.2012.08.005 |
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著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/117846 | |||||
識別子タイプ | HDL |