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Inflammatory and degranulation effect of yellow sand on RBL-2H3 cells in relation to chemical and biological constituents
http://hdl.handle.net/2241/117708
http://hdl.handle.net/2241/117708e7a91e2e-bd00-4323-81af-837cf1bdfcbd
名前 / ファイル | ライセンス | アクション |
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EES-84-9-17.pdf (1.3 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-10-26 | |||||
タイトル | ||||||
タイトル | Inflammatory and degranulation effect of yellow sand on RBL-2H3 cells in relation to chemical and biological constituents | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yamada, Parida
× Yamada, Parida× Hatta, Tamao× Du, Mingyuan× Wakimizu, Kenji× Han, Junkyu× Maki, Taichi× Isoda, Hiroko |
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著者別名 |
礒田, 博子
× 礒田, 博子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent studie pointed out that allergic diseases have increased during the Asian dust storm event (ADSE) in Japan. Daily observations and the atmospheric concentrations of yellow sand (YS) aerosol have been increasing. In this study, YS samples collected from three sites of Japan during ADSE in 2009–2010 were used. The particles were analyzed by X-ray photoelectron spectroscopy (XPS) and X-ray fluorescence—energy dispersive spectrometer (XRF-EDS). We investigate ability of YS extract on enhancing the chemical mediator release and cytokine production from rat basophilic leukemia (RBL-2H3) cells. The dust particles at Fukuoka and Tsukuba were abundant in aluminum (Al), iron (Fe), potassium (K) and titan (Ti) than those at Naha. Concentration of the trace endotoxin and Cryptomeria japonica pollen allergen (Cry j 1) were measured in YS extract. After exposure of RBL-2H3 cells to YS extract, the β-hexosaminidase (β-hex) release, tumor necrosis factor-alpha (TNF-α) production were enhanced in RBL-2H3 cells. This process depends on endotoxin, Cry j 1 and other allergen present in the YS extract. YS water extract also show a strong cytotoxic effect on the cells. This data suggest that low levels of endotoxin and Cry j 1 in YS may cause allergy during the ADSE. | |||||
書誌情報 |
Ecotoxicology and environmental safety 巻 84, p. 9-17, 発行日 2012-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0147-6513 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00179452 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22835726 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ecoenv.2012.05.021 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Inc. NOTICE: this is the author's version of a work that was accepted for publication in Ecotoxicology and Environmental Safety. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Ecotoxicology and Environmental Safety, Vol.84, Pages:9-17. doi:10.1016/j.ecoenv.2012.05.021. |
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著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/117708 | |||||
識別子タイプ | HDL |