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Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells
http://hdl.handle.net/2241/117705
http://hdl.handle.net/2241/1177051ce3182f-bb28-4e51-bc60-f8eb182fe260
名前 / ファイル | ライセンス | アクション |
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Cy_64-3.pdf (739.5 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-10-26 | |||||
タイトル | ||||||
タイトル | Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Omri, Abdelfatteh E. L.
× Omri, Abdelfatteh E. L.× Han, Junkyu× Abdrabbah, Manef Ben× Isoda, Hiroko |
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著者別名 |
韓, 畯奎
× 韓, 畯奎× 礒田, 博子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Polyphenols are known to exhibit wide spectrum of benefit for brain health and to protect from several neurodegenerative diseases. The present study was sought to determine the neuroprotective effects of Rosmarinus officinalis’ polyphenols (luteolin, carnosic acid, and rosmarinic acid) through the investigation of stress-related proteins. We carried out measurement of the expression of heat-shock protein (Hsp) 47 promoter in heat stressed Chinese hamster ovary transfected cells. We performed proteomic analysis and confirmed gene expression by real time PCR in PC12 cells. Results showed that these compounds modulated significant and different effects on the expression of 4 stress-related proteins: heat shock protein 90 α (Hsp90), Transitional endoplasmic reticulum ATPase (VCP/p97), Nucleoside diphosphate kinase (NDK), and Hypoxia up-regulated protein 1 (HYOU1)) at translational and post translational levels in PC12 cells and they downregulated the expression of Hsp47 activity in Chinese hamster transformed cells. These findings suggest that luteolin, carnosic acid, and rosmarinic acid may modulate the neuroprotective defense system against cellular stress insults and increase neuro-thermotolerance. | |||||
書誌情報 |
Cytotechnology 巻 64, 号 3, p. 231-240, 発行日 2012-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0920-9069 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10678299 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 21861121 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10616-011-9352-y | |||||
権利 | ||||||
権利情報 | © Springer Science+Business Media B.V. 2011 The original publication is available at www.springerlink.com |
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著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Springer Science+Business Media B.V. | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/117705 | |||||
識別子タイプ | HDL |