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Effects of alkyl chain length of gallate on self-association and membrane-binding
http://hdl.handle.net/2241/117483
http://hdl.handle.net/2241/11748314bdabb2-0705-4462-b1ce-32d9624133e4
名前 / ファイル | ライセンス | アクション |
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JOB_150-2.pdf (640.2 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-08-31 | |||||
タイトル | ||||||
タイトル | Effects of alkyl chain length of gallate on self-association and membrane-binding | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Takai, Eisuke
× Takai, Eisuke× Hirano, Atsushi× Shiraki, Kentaro |
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著者別名 |
白木, 賢太郎
× 白木, 賢太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Alkyl gallates are anticipated for their use as antibacterial and antiviral agents. Although their pharmacological activities depend on their alkyl chain length, no mechanism has yet been clarified. As described herein, we investigated the membrane binding properties of a series of alkyl gallates using fluorescence measurement to elucidate their different pharmacological activities. Membrane binding of the alkyl gallates increased concomitantly with increasing alkyl chain length, except for cetyl gallate and stearyl gallate. Dynamic light scattering revealed that alkyl gallates with a long alkyl chain are prone to self-association in the solution. Membrane binding abilities of the alkyl gallates are correlated with antibacterial and antivirus activities, as described in previous reports. The partition constants of the alkyl gallates to lipid membranes depend on the membrane components and the membrane phase. Self-association and lipid binding of the alkyl gallates might be primary biophysical factors associated with their pharmacological activities. | |||||
書誌情報 |
The journal of biochemistry 巻 150, 号 2, p. 165-171, 発行日 2011-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-924X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00694073 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 21508039 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jb/mvr048 | |||||
権利 | ||||||
権利情報 | © The authors 2011. Published by Oxford University Press on behalf of the Japanese Biochemical Society | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Oxford University Press | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/117483 | |||||
識別子タイプ | HDL |