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Protective effects of exogenous GM-1 ganglioside on acoustic injury of the mouse cochlea
http://hdl.handle.net/2241/106955
http://hdl.handle.net/2241/10695573227e3f-eb49-4169-8909-b1ca05254bac
名前 / ファイル | ライセンス | アクション |
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NSL_473-3.pdf (202.0 kB)
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Fig.pdf (224.2 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2010-12-08 | |||||
タイトル | ||||||
タイトル | Protective effects of exogenous GM-1 ganglioside on acoustic injury of the mouse cochlea | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tanaka, Shuho
× Tanaka, Shuho× Tabuchi, Keiji× Hoshino, Tomofumi× Murashita, Hidekazu× Tsuji, Shigeki× Hara, Akira |
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著者別名 |
田中, 秀峰
× 田中, 秀峰× 田渕, 経司× 星野, 朝文× 原, 晃 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | GM-1 ganglioside (GM-1), a glycosphingolipid, is embedded in the lipid layer of neuronal membranes and is one of the neuroprotective agents. To the best of our knowledge, the role of GM-1 has never been examined in hair cell injury. The purpose of this study was therefore to evaluate the effects of GM-1 on acoustic injury of the cochlea. Mice were exposed to 4-kHz pure tone of 128 dB SPL (sound pressure level) for 4 h. GM-1 was intraperitoneally administered immediately before the onset of acoustic overexposure. The threshold shift of the auditory brainstem response (ABR) and hair cell loss were then evaluated 2 weeks after acoustic overexposure. Immunostaining for 4-hydroxynonenal (4-HNE), indicative of lipid peroxidation, was also examined in animals subjected to acoustic overexposure. GM-1 treatment significantly decreased the ABR threshold shifts and hair cell loss after acoustic overexposure. And immunostaining for 4-HNE was reduced by GM-1 treatment. These findings suggest that GM-1 is involved in the protection of the cochlea against acoustic injury through inhibiting lipid peroxidation. | |||||
書誌情報 |
Neuroscience letters 巻 473, 号 3, p. 237-241, 発行日 2010-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0304-3940 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00754925 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 20219629 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.neulet.2010.02.057 | |||||
権利 | ||||||
権利情報 | © 2010 Elsevier Ireland Ltd | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/106955 | |||||
識別子タイプ | HDL |